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Instituto de Investigação em Ciências da Vida e da Saúde : [602]

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Research lines developed by the 3 Research Domains of the ICVS, Infectious Diseases , Neurosciences and Development & Neoplasia :

A – Infectious Diseases

   •  The study of the neurodegenerative disorder Batten disease
   •  Human genetic factors predisposing susceptibility to invasive fungal infections
   •  Identification of clinically relevant fungi causing systemic mycosis
   •  Cellular and molecular studies in the pathogenic fungi Paracoccidioides brasiliensis: Dimorphism and its regulation by steroid hormones
   •  Epidemiology profile of dermatophytosis in Braga
   •  Elucidation of the mechanisms of action of non-conventional antifungal agents
   •  Exploitation of yeast as a model to study mitochondrial diseases and neurodegenerative disorder Batten disease
   •  Apoptotic pathway(s) in Saccharomyces cerevisiae: proteomic profile and metacaspase-interactive molecules
   •  Identification of pathogenic fungi secreted compounds
•  Biology of infection in mycobacteriosis of difficult treatment- Buruli Ulcer
   •  Understanding BCG infection/vaccination; role of IFN-gamma and IL-17
•  Role of anti-inflammatory cytokines in allograft rejection
   •  Expression and activation of murine Toll-like receptors in B lymphocytes
•  Development of drug delivery systems for the treatment of mycobaceriosis

B – Neurosciences

   •  Neuronal turnover regulation and its relevance for pathology
   •  From stress to cognition and pain: the role of corticosteroids and CRF
   •  Descending pain modulating networks
   •  Anatomical basis for the sensorymotor processing in the laryngeal mucosa
   •  Improving treatment of trigeminal neuralgia (TN) and epidemiology of TN in Portugal
   •  Studies on the role of transthyretin in energy metabolism
•  Molecular basis of schizophrenia: the retinoid and thyroid hormone hypotheses
   •  Characterization of the iodine status in young women from Minho region and its relationship with the psychomotor development of the newborns
   •  Functional genomics of Machado-Joseph disease
   •  Rett Syndrome
   •  Functional characterization of the MECP2 3'UTR

C – Development and Neoplasia

   •  Analysis of myopithelial component role in breast cancer development
   •  Analysis of DNA repair gene polymorphisms in a group of breast cancer patients from Portuguese origin
   •  Study of lymphangiogenesis in vascular lesions and breast cancer
   •  Analysis of receptor tyrosine kinases and intracellular signaling pathway alterations in gliomas
   •  Role of COX-2 and TP in the antitumoral response to Capecitabine in Hand and Foot Syndrome animal model
   •  The molecular clock is operating during limb bud development
   •  Characterization of the molecular clock components by using the yeast Two-Hybrid technology
   •  Subtraction screening to identify medial presomitic mesoderm genes
   •  Molecular and temporal characterization of the rostral-most somites in early somitic stages of the chick embryo
   •  The role of ghrelin in normal and hypoplastic fetal lung
   •  Prognostic factors in experimental and human congenital diaphragmatic hernia (CDH)
   •  The role of inflammatory mediators in normal and hypoplastic lung
   •  Induction of fetal lung growth by overexpression of growth factors through viral gene transfer in CDH rat model
   •  In utero fate mapping of Aorta-Gonad-Mesonephros cells
   •  Myocardium hypertrophy and pregnancy
   •  Fetal heart development in congenital diaphragmatic hernia
   •  Ghrelin expression and function during fetal heart development

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