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TitlePerformance of 3 methods for quality control for gynecologic cytology diagnoses
Author(s)Utagawa, Maria Lúcia
Shirata, Neuza Kasumi
Ferraz, Maria da Gloria Mattosinho de Castro
Loreto, Celso di
Dall’ Agnol, Miria
Longatto Filho, Adhemar
KeywordsCytologic technique
Papanicolaou smear
Quality control
Issue date2008
PublisherKarger Publishers
JournalActa Cytologica
Abstract(s)ObjectiveTo evaluate performance and viability of internal quality control QC) strategies in a public health laboratory of the state of Sao Paulo.Study DesignA retrospective study was per formed with 3 QC strategies to improve internal cytologic diagnoses: morphologic guided-list criteria (MGLC), 100% rapid-rescreening (100% RR) of negative slides ("turret" method) and 10% rescreening (10% R) of negative slides. Cases were examined at Adolfo Lutz Institute, Sao Paulo, Brazil, from 2002 to 2004. Histopathologic results, when available, were considered gold standard; cytologic consensus diagnosis was by 2 pathologists when histologic results were unavailable.ResultsMGLC selected 20.7% samples with cytologic atypias, 10% R selected 0.6% and RR selected 2.5%. Cytologic/histologic initial concordance was 57.4%, low-grade squamous intraepithelial lesion false negative rate was 34.9% and high-grade squamous intraepithelial lesion false negative rate was 12.2%. After diagnosis, consensus concordance was 97.2%.ConclusionThe 100% RR and 10% R QC strategies detected more false negative cases in liquid-based cytology than in conventional Pap smears. The 100% RR strategy reduced the false negative results and allowed evaluation of individual staff performance. The 10% R strategy did not offer significant results. We concluded that association of MGLC and 100% RR strategies might improve cytologic diagnostic quality.
DescriptionProva tipográfica (In Press)
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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