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https://hdl.handle.net/1822/74704
Título: | Biopolymer films doped with silver(I) coordination polymers against bacterial biofilms |
Autor(es): | Fernandes, T. A. Costa, I. F. M. Jorge, Paula Alexandra Silva Sousa, A. C. André, V. Cerca, Nuno Kirillov, A. M. |
Data: | 14-Jul-2021 |
Editora: | Sociedade de Portuguesa de Química (SPQ) |
Citação: | Fernandes, T. A.; Costa, I. F. M.; Jorge, Paula; Sousa, A. C.; André, V.; Cerca, Nuno; Kirillov, A. M., Biopolymer films doped with silver(I) coordination polymers against bacterial biofilms. XXVI National Meeting of the Portuguese Chemical Society - Book of Abstracts. No. P100, Braga, Portugal, July 14-16, 305, 2021. ISBN: 978-989-8124-33-3 |
Resumo(s): | This report describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) as well their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag4(8-H2pma)2]n·4nH2O (1) and [Ag5(6-H0.5tma)2(H2O)4]n·2nH2O (2) were generated from AgNO3 and pyromellitic (H4pma) or trimesic (H3tma) acid, also using N,N-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used to create new hybrid materials, namely by doping the [ESOA]n biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to inhibit bacterial biofilm formation was investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) coordination polymers and derived biopolymer films showed activity against all the tested bacteria in a concentration dependent manner. Compound 1 was far more active, especially in preventing biofilm formation, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). Thus, the present study expands the antibiofilm applications of CP-doped biopolymers, offering new perspectives and promising results for the design of functional biomaterials (Scheme 1). |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/74704 |
ISBN: | 978-989-8124-33-3 |
Versão da editora: | https://xxviienspq.events.chemistry.pt/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55005_1.pdf | 439,76 kB | Adobe PDF | Ver/Abrir |