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https://hdl.handle.net/1822/74704
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Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, T. A. | por |
dc.contributor.author | Costa, I. F. M. | por |
dc.contributor.author | Jorge, Paula Alexandra Silva | por |
dc.contributor.author | Sousa, A. C. | por |
dc.contributor.author | André, V. | por |
dc.contributor.author | Cerca, Nuno | por |
dc.contributor.author | Kirillov, A. M. | por |
dc.date.accessioned | 2021-11-15T13:56:21Z | - |
dc.date.available | 2021-11-15T13:56:21Z | - |
dc.date.issued | 2021-07-14 | - |
dc.identifier.citation | Fernandes, T. A.; Costa, I. F. M.; Jorge, Paula; Sousa, A. C.; André, V.; Cerca, Nuno; Kirillov, A. M., Biopolymer films doped with silver(I) coordination polymers against bacterial biofilms. XXVI National Meeting of the Portuguese Chemical Society - Book of Abstracts. No. P100, Braga, Portugal, July 14-16, 305, 2021. ISBN: 978-989-8124-33-3 | por |
dc.identifier.isbn | 978-989-8124-33-3 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74704 | - |
dc.description.abstract | This report describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) as well their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag4(8-H2pma)2]n·4nH2O (1) and [Ag5(6-H0.5tma)2(H2O)4]n·2nH2O (2) were generated from AgNO3 and pyromellitic (H4pma) or trimesic (H3tma) acid, also using N,N-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used to create new hybrid materials, namely by doping the [ESOA]n biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to inhibit bacterial biofilm formation was investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) coordination polymers and derived biopolymer films showed activity against all the tested bacteria in a concentration dependent manner. Compound 1 was far more active, especially in preventing biofilm formation, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). Thus, the present study expands the antibiofilm applications of CP-doped biopolymers, offering new perspectives and promising results for the design of functional biomaterials (Scheme 1). | por |
dc.description.sponsorship | This work was supported by the Foundation for Science and Technology (FCT) and Portugal 2020 (projects PTDC/QUI-QIN/29697/2017, LISBOA-01-0145-FEDER-029697, UIDB/00100/2020, UIDP/00100/2020, IPL/2020/HyBioPol and REM2013), contracts CEECIND/02725/2018 and CEECIND/00194/2020. | por |
dc.language.iso | eng | por |
dc.publisher | Sociedade de Portuguesa de Química (SPQ) | por |
dc.relation | PTDC/QUI-QIN/29697/2017 | por |
dc.relation | LISBOA-01-0145-FEDER-029697 | por |
dc.relation | UIDB/00100/2020 | por |
dc.relation | UIDP/00100/2020 | por |
dc.rights | openAccess | por |
dc.title | Biopolymer films doped with silver(I) coordination polymers against bacterial biofilms | por |
dc.type | conferenceAbstract | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://xxviienspq.events.chemistry.pt/ | por |
dc.comments | CEB55005 | por |
sdum.event.type | meeting | por |
oaire.citationStartPage | 305 | por |
oaire.citationIssue | P100 | - |
oaire.citationConferencePlace | Braga, Portugal | por |
dc.date.updated | 2021-11-15T12:53:16Z | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.conferencePublication | XXVI National Meeting of the Portuguese Chemical Society - Book of Abstracts | por |
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