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https://hdl.handle.net/1822/64305
Título: | The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats |
Autor(es): | Leite-Almeida, Hugo Torres, Luis Almeida Mesquita, Ana Raquel Marcelino Pertovaara, Antti Sousa, Nuno Cerqueira, João José Almeida, Armando |
Palavras-chave: | Aging Analysis of variance Animals Cognition disorders Disease models, Animal Emotions Exploratory behavior Locomotion Male Maze learning Memory, short-term Neuropsychological tests Pain measurement Peripheral nervous system diseases Rats Rats, Wistar Swimming Sural nerve Neuropathic pain Experimental neuropathy Animal model Emotional behaviours Cognition |
Data: | Jul-2009 |
Editora: | Elsevier 1 |
Revista: | Pain |
Resumo(s): | Chronic pain syndromes encompass several clinical entities that frequently affect the individuals' emotional and cognitive behaviours which, in turn, can also alter pain perception. Additionally, both pain perception and motivational-affective behaviours change with increasing age. In order to evaluate the influence of age upon the interaction between chronic pain and affective/cognitive behaviours, 3-, 10- and 22-month-old rats with 1 month neuropathy (spared nerve injury, SNI model) were compared with age-matched sham-operated controls in the open field (OF; locomotor and exploratory behaviours), elevated plus-maze (EPM; anxiety-like behaviour), forced swimming (FST; depressive-like behaviour), working memory water maze (WM; spatial short-term memory), Morris water maze (MWM; spatial reference memory) and spatial reversal (behavioural flexibility) tests. Locomotor and exploratory activities decreased steadily with age and were further reduced by SNI. Aging was associated with increased anxiety-like behaviour, which was potentiated by SNI in both 3- and 22-month-old rats. The performance in the FST was affected by SNI but only in mid-aged animals. Cognitive performances in the MWM and spatial reversal tests deteriorated with age; however, the SNI lesion was only detrimental in the reversal task to mid-aged animals. Our data demonstrate that the influence of neuropathic pain on affective and cognitive behaviours is age dependent and varies with the behavioural domain that is tested. Importantly, mid-aged animals seem to be more susceptible to depression and cognitive deterioration associated to chronic pain than young and old groups. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/64305 |
DOI: | 10.1016/j.pain.2009.02.024 |
ISSN: | 0304-3959 |
e-ISSN: | 1872-6623 |
Versão da editora: | https://www.sciencedirect.com/science/article/abs/pii/S0304395909001390#! |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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leite-almeida2009.pdf Acesso restrito! | 605,22 kB | Adobe PDF | Ver/Abrir |