Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/64305
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Leite-Almeida, Hugo | por |
dc.contributor.author | Torres, Luis Almeida | por |
dc.contributor.author | Mesquita, Ana Raquel Marcelino | por |
dc.contributor.author | Pertovaara, Antti | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Cerqueira, João José | por |
dc.contributor.author | Almeida, Armando | por |
dc.date.accessioned | 2020-03-06T14:58:03Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 0304-3959 | - |
dc.identifier.uri | https://hdl.handle.net/1822/64305 | - |
dc.description.abstract | Chronic pain syndromes encompass several clinical entities that frequently affect the individuals' emotional and cognitive behaviours which, in turn, can also alter pain perception. Additionally, both pain perception and motivational-affective behaviours change with increasing age. In order to evaluate the influence of age upon the interaction between chronic pain and affective/cognitive behaviours, 3-, 10- and 22-month-old rats with 1 month neuropathy (spared nerve injury, SNI model) were compared with age-matched sham-operated controls in the open field (OF; locomotor and exploratory behaviours), elevated plus-maze (EPM; anxiety-like behaviour), forced swimming (FST; depressive-like behaviour), working memory water maze (WM; spatial short-term memory), Morris water maze (MWM; spatial reference memory) and spatial reversal (behavioural flexibility) tests. Locomotor and exploratory activities decreased steadily with age and were further reduced by SNI. Aging was associated with increased anxiety-like behaviour, which was potentiated by SNI in both 3- and 22-month-old rats. The performance in the FST was affected by SNI but only in mid-aged animals. Cognitive performances in the MWM and spatial reversal tests deteriorated with age; however, the SNI lesion was only detrimental in the reversal task to mid-aged animals. Our data demonstrate that the influence of neuropathic pain on affective and cognitive behaviours is age dependent and varies with the behavioural domain that is tested. Importantly, mid-aged animals seem to be more susceptible to depression and cognitive deterioration associated to chronic pain than young and old groups. | por |
dc.description.sponsorship | This study was supported by Calouste Gulbenkian Foundation Project No. 74551 and Grünenthal Foundation (Portugal). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | closedAccess | por |
dc.subject | Aging | por |
dc.subject | Analysis of variance | por |
dc.subject | Animals | por |
dc.subject | Cognition disorders | por |
dc.subject | Disease models, Animal | por |
dc.subject | Emotions | por |
dc.subject | Exploratory behavior | por |
dc.subject | Locomotion | por |
dc.subject | Male | por |
dc.subject | Maze learning | por |
dc.subject | Memory, short-term | por |
dc.subject | Neuropsychological tests | por |
dc.subject | Pain measurement | por |
dc.subject | Peripheral nervous system diseases | por |
dc.subject | Rats | por |
dc.subject | Rats, Wistar | por |
dc.subject | Swimming | por |
dc.subject | Sural nerve | por |
dc.subject | Neuropathic pain | por |
dc.subject | Experimental neuropathy | por |
dc.subject | Animal model | por |
dc.subject | Emotional behaviours | por |
dc.subject | Cognition | por |
dc.title | The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S0304395909001390#! | por |
oaire.citationStartPage | 57 | por |
oaire.citationEndPage | 65 | por |
oaire.citationIssue | 1-2 | por |
oaire.citationVolume | 144 | por |
dc.identifier.eissn | 1872-6623 | - |
dc.identifier.doi | 10.1016/j.pain.2009.02.024 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 19398158 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pain | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
leite-almeida2009.pdf Acesso restrito! | 605,22 kB | Adobe PDF | Ver/Abrir |