Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64303

TitleChronic stress causes frontostriatal reorganization and affects decision-making
Author(s)Dias-Ferreira, Eduardo
Sousa, João Carlos
Melo, Irene
Morgado, Pedro
Mesquita, Ana R.
Cerqueira, João José
Costa, Rui M.
Sousa, Nuno
KeywordsAnimals
Atrophy
Cell Count
Choice Behavior
Chronic Disease
Corpus Striatum
Dendrites
Frontal Lobe
Habits
Hypertrophy
Neural Pathways
Neurons
Prefrontal Cortex
Rats
Rats, Long-Evans
Rats, Wistar
Reinforcement, Psychology
Stress, Psychological
Decision Making
Issue date31-Jul-2009
PublisherAmerican Association for the Advancement of Science
JournalScience
Abstract(s)The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.
TypeArticle
URIhttp://hdl.handle.net/1822/64303
DOI10.1126/science.1171203
ISSN0036-8075
e-ISSN1095-9203
Publisher versionhttps://science.sciencemag.org/content/325/5940/621
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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