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https://hdl.handle.net/1822/64303
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Dias-Ferreira, Eduardo | por |
dc.contributor.author | Sousa, João Carlos | por |
dc.contributor.author | Melo, Irene | por |
dc.contributor.author | Morgado, Pedro | por |
dc.contributor.author | Mesquita, Ana R. | por |
dc.contributor.author | Cerqueira, João José | por |
dc.contributor.author | Costa, Rui M. | por |
dc.contributor.author | Sousa, Nuno | por |
dc.date.accessioned | 2020-03-06T14:28:32Z | - |
dc.date.issued | 2009-07-31 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://hdl.handle.net/1822/64303 | - |
dc.description.abstract | The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit. | por |
dc.description.sponsorship | E.D.-F.,J.C.S., and A.R.M. received fellowships from the Portuguese Foundation for Science and Technology. This work was supported by the Bial Foundation (134/06), the ICVS, and the Division of Intramural Clinical and Basic Research, NIAAA, NIH. | por |
dc.language.iso | eng | por |
dc.publisher | American Association for the Advancement of Science | por |
dc.relation | 134/06 | por |
dc.rights | restrictedAccess | por |
dc.subject | Animals | por |
dc.subject | Atrophy | por |
dc.subject | Cell Count | por |
dc.subject | Choice Behavior | por |
dc.subject | Chronic Disease | por |
dc.subject | Corpus Striatum | por |
dc.subject | Dendrites | por |
dc.subject | Frontal Lobe | por |
dc.subject | Habits | por |
dc.subject | Hypertrophy | por |
dc.subject | Neural Pathways | por |
dc.subject | Neurons | por |
dc.subject | Prefrontal Cortex | por |
dc.subject | Rats | por |
dc.subject | Rats, Long-Evans | por |
dc.subject | Rats, Wistar | por |
dc.subject | Reinforcement, Psychology | por |
dc.subject | Stress, Psychological | por |
dc.subject | Decision Making | por |
dc.title | Chronic stress causes frontostriatal reorganization and affects decision-making | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://science.sciencemag.org/content/325/5940/621 | por |
oaire.citationStartPage | 621 | por |
oaire.citationEndPage | 625 | por |
oaire.citationIssue | 5940 | por |
oaire.citationVolume | 325 | por |
dc.identifier.eissn | 1095-9203 | - |
dc.identifier.doi | 10.1126/science.1171203 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 19644122 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Science | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Dias-ferreira-2009-Chronic-stress-causes-frontostriata.pdf Acesso restrito! | 531,73 kB | Adobe PDF | Ver/Abrir |