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https://hdl.handle.net/1822/61613
Título: | Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival |
Autor(es): | Paredes, Joana Correia, Ana Luisa Ribeiro, Ana Sofia Milanezi, Maria Fernanda Grillo Cameselle-Teijeiro, J. Schmitt, F. C. |
Palavras-chave: | Adult Aged Aged, 80 and over Biomarkers, Tumor Breast Neoplasms Cadherins Catenins Cytoplasm Female Humans Membrane Proteins Middle Aged Neoplasm Invasiveness Neoplasm Proteins Survival Analysis |
Data: | Jul-2008 |
Editora: | BMJ Publishing Group |
Revista: | Journal of Clinical Pathology |
Resumo(s): | Background: Changes in junctional catenin expression may compromise cadherin-mediated adhesion, increasing cell malignant properties such as invasive and metastatic abilities. Altered expression of alpha-, beta-, gamma- and p120-catenin has been reported to be associated with E-cadherin loss or decreased expression, in both breast carcinomas and breast cancer cell lines. Aims and Methods: To investigate the expression and subcellular localisation of p120- and beta-catenin in a series of human invasive breast carcinomas, and correlate it with biological markers and clinicopathological parameters. Results: Both catenins frequently exhibited a reduced membranous or cytoplasmic staining pattern. These alterations were significantly correlated with lack of both E-cadherin and oestrogen receptor-alpha expression. It was possible to associate the expression of beta-catenin with histological grade, tumour size and nodal status, suggesting a relevant role for this catenin as a prognostic factor. The majority of E- and P-cadherin co-expressing tumours were related to cytoplasmic expression of p120-catenin; in this group of breast carcinomas, patient survival was poor. Conclusion: Results indicate that p120-catenin cytoplasmic accumulation may play an important role in mediating the oncogenic effects derived from P-cadherin aberrant expression, including enhanced motility and invasion, particularly in tumours which maintain E-cadherin expression. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61613 |
DOI: | 10.1136/jcp.2007.052704 |
ISSN: | 0021-9746 |
e-ISSN: | 1472-4146 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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paredes2008.pdf Acesso restrito! | 212,81 kB | Adobe PDF | Ver/Abrir |