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https://hdl.handle.net/1822/61613
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Paredes, Joana | por |
dc.contributor.author | Correia, Ana Luisa | por |
dc.contributor.author | Ribeiro, Ana Sofia | por |
dc.contributor.author | Milanezi, Maria Fernanda Grillo | por |
dc.contributor.author | Cameselle-Teijeiro, J. | por |
dc.contributor.author | Schmitt, F. C. | por |
dc.date.accessioned | 2019-10-04T14:14:39Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61613 | - |
dc.description.abstract | Background: Changes in junctional catenin expression may compromise cadherin-mediated adhesion, increasing cell malignant properties such as invasive and metastatic abilities. Altered expression of alpha-, beta-, gamma- and p120-catenin has been reported to be associated with E-cadherin loss or decreased expression, in both breast carcinomas and breast cancer cell lines. Aims and Methods: To investigate the expression and subcellular localisation of p120- and beta-catenin in a series of human invasive breast carcinomas, and correlate it with biological markers and clinicopathological parameters. Results: Both catenins frequently exhibited a reduced membranous or cytoplasmic staining pattern. These alterations were significantly correlated with lack of both E-cadherin and oestrogen receptor-alpha expression. It was possible to associate the expression of beta-catenin with histological grade, tumour size and nodal status, suggesting a relevant role for this catenin as a prognostic factor. The majority of E- and P-cadherin co-expressing tumours were related to cytoplasmic expression of p120-catenin; in this group of breast carcinomas, patient survival was poor. Conclusion: Results indicate that p120-catenin cytoplasmic accumulation may play an important role in mediating the oncogenic effects derived from P-cadherin aberrant expression, including enhanced motility and invasion, particularly in tumours which maintain E-cadherin expression. | por |
dc.description.sponsorship | This work was supported by three research grants (JP: SFRH/BPD/15319/ 2005; ALC: POCI/N/07.01.02/10/25/2005; ASR: POCI/BIA-BCM/59252/2004) and by a scientific project (POCI/BIA-BCM/59252/2004), all financed by the Portuguese Science and Technology Foundation. We are grateful to the Calouste Gulbenkian Foundation for the ‘‘Programa Gulbenkian de Estímulo à Investigação (FCG 55/05)’’. | por |
dc.language.iso | eng | por |
dc.publisher | BMJ Publishing Group | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F15319%2F2005/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/59252/PT | por |
dc.rights | closedAccess | por |
dc.subject | Adult | por |
dc.subject | Aged | por |
dc.subject | Aged, 80 and over | por |
dc.subject | Biomarkers, Tumor | por |
dc.subject | Breast Neoplasms | por |
dc.subject | Cadherins | por |
dc.subject | Catenins | por |
dc.subject | Cytoplasm | por |
dc.subject | Female | por |
dc.subject | Humans | por |
dc.subject | Membrane Proteins | por |
dc.subject | Middle Aged | por |
dc.subject | Neoplasm Invasiveness | por |
dc.subject | Neoplasm Proteins | por |
dc.subject | Survival Analysis | por |
dc.title | Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 856 | por |
oaire.citationEndPage | 862 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 61 | por |
dc.identifier.eissn | 1472-4146 | - |
dc.identifier.doi | 10.1136/jcp.2007.052704 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 18381381 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Clinical Pathology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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paredes2008.pdf Acesso restrito! | 212,81 kB | Adobe PDF | Ver/Abrir |