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https://hdl.handle.net/1822/50207
Título: | Institutionalization and indiscriminate social behavior: differential-susceptibility versus diathesis-stress models for the 5-HTTLPR and BDNF genotypes |
Autor(es): | Mesquita, Ana Raquel Marcelino Belsky, J. Li, Z. Baptista, J. Carvalho-Correia, Eduarda Maciel, P. Soares, Isabel |
Palavras-chave: | Brain-Derived Neurotrophic Factor Child Child, Institutionalized Child, Preschool Family Gene-Environment Interaction Genetic Predisposition to Disease Genotype Interview, Psychological Models, Genetic Serotonin Plasma Membrane Transport Proteins Polymorphism, Genetic Social Behavior Institutionalization Indiscriminate behavior BDNF 5-HTTLPR Diathesis-stress Differential susceptibility |
Data: | Set-2015 |
Editora: | Elsevier 1 |
Revista: | Physiology & Behavior |
Resumo(s): | Institutionalization adversely impacts children's emotional functioning, proving related to attachment disorders, perhaps most notably that involving indiscriminate behavior, the subject of this report. In seeking to extend work in this area, this research on gene X environment (GXE) interplay investigated whether the serotonin transporter (5-HTTLPR) and val66met Brain-Derived Neurotrophic Factor (BDNF) polymorphisms moderated the effect of institutional care on indiscriminate behavior in preschoolers. Eighty-five institutionalized and 135 home-reared Portuguese children were assessed using Disturbances of Attachment Interview (DAI). GXE results indicated that s/s homozygotes of the 5-HTTLPR gene displayed significantly higher levels of indiscriminate behavior than all other children if institutionalized, something not true of such children when family reared. These findings proved consistent with the diathesis-stress rather than differential-susceptibility model of person×environment interaction. BDNF proved unrelated to indiscriminate behavior. Results are discussed in relation to previous work on this subject of indiscriminate behavior, institutionalization and GXE interaction. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/50207 |
DOI: | 10.1016/j.physbeh.2015.09.015 |
ISSN: | 0031-9384 |
e-ISSN: | 1873-507X |
Versão da editora: | www.elsevier.com/locate/phb |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CIPsi - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2015 Institutionalization and indiscriminate social behavior Differential-susceptibility versus diathesis-stress models for the.pdf Acesso restrito! | 336,07 kB | Adobe PDF | Ver/Abrir |