Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50207

TitleInstitutionalization and indiscriminate social behavior: differential-susceptibility versus diathesis-stress models for the 5-HTTLPR and BDNF genotypes
Author(s)Mesquita, Ana Raquel Marcelino
Belsky, J.
Li, Z.
Baptista, J.
Carvalho-Correia, Eduarda
Maciel, P.
Soares, Isabel
KeywordsBrain-Derived Neurotrophic Factor
Child
Child, Institutionalized
Child, Preschool
Family
Gene-Environment Interaction
Genetic Predisposition to Disease
Genotype
Interview, Psychological
Models, Genetic
Serotonin Plasma Membrane Transport Proteins
Polymorphism, Genetic
Social Behavior
Institutionalization
Indiscriminate behavior
BDNF
5-HTTLPR
Diathesis-stress
Differential susceptibility
Issue dateSep-2015
PublisherElsevier
JournalPhysiology & Behavior
Abstract(s)Institutionalization adversely impacts children's emotional functioning, proving related to attachment disorders, perhaps most notably that involving indiscriminate behavior, the subject of this report. In seeking to extend work in this area, this research on gene X environment (GXE) interplay investigated whether the serotonin transporter (5-HTTLPR) and val66met Brain-Derived Neurotrophic Factor (BDNF) polymorphisms moderated the effect of institutional care on indiscriminate behavior in preschoolers. Eighty-five institutionalized and 135 home-reared Portuguese children were assessed using Disturbances of Attachment Interview (DAI). GXE results indicated that s/s homozygotes of the 5-HTTLPR gene displayed significantly higher levels of indiscriminate behavior than all other children if institutionalized, something not true of such children when family reared. These findings proved consistent with the diathesis-stress rather than differential-susceptibility model of person×environment interaction. BDNF proved unrelated to indiscriminate behavior. Results are discussed in relation to previous work on this subject of indiscriminate behavior, institutionalization and GXE interaction.
TypeArticle
URIhttp://hdl.handle.net/1822/50207
DOI10.1016/j.physbeh.2015.09.015
ISSN0031-9384
e-ISSN1873-507X
Publisher versionwww.elsevier.com/locate/phb
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CIPsi - Artigos (Papers)


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