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TitlePatterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict
Author(s)Jacinto, Luís Ricardo Monteiro
Cerqueira, João José
Sousa, Nuno
Local field potentials
Ventral hippocampus
Prefrontal cortex
Issue date18-Sep-2016
PublisherFrontiers Media
JournalFrontiers in Behavioral Neuroscience
CitationJacinto, L. R., Cerqueira, J. J., & Sousa, N. (2016). Patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict. [Article]. Frontiers in Behavioral Neuroscience, 10(SEP). doi: 10.3389/fnbeh.2016.00171
Abstract(s)Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (FPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA), and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA, and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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