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https://hdl.handle.net/1822/44064| Título: | Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles |
| Autor(es): | Soares, Ana M. S. Hungerford, Graham Costa, Susana P. G. Gonçalves, M. Sameiro T. |
| Palavras-chave: | Prodrugs Coumarins Oxazoles Butyric acid Photocleavable protecting groups Photolysis |
| Data: | 2017 |
| Editora: | Elsevier 1 |
| Revista: | Dyes and Pigments |
| Citação: | A. M. S. Soares, G. Hungerford, S. P. G. Costa M. S. T. Gonçalves, “Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles”, Dyes and Pigments, 2017, 137, 91-100. |
| Resumo(s): | New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at position 2 of the heterocyclic system were used in the synthesis of ester conjugates of butyric acid. Photolysis at selected wavelengths in methanol/HEPES buffer (80:20) solutions, monitored by HPLC/UV and 1H NMR, produced the complete release of butyric acid. The shorter irradiation times for cleavage at longer wavelengths occurred for the conjugate with a 4-oxo-4H-benzopyran-2-yl substituent and thus (6-oxo-2-(4-oxo-4H-benzopyran-2-yl)-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl has potential as a candidate photosensitive moiety for butyric acid prodrugs. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/44064 |
| DOI: | 10.1016/j.dyepig.2016.10.001 |
| ISSN: | 0143-7208 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| -MSTG-Final revised manuscript.pdf | 855,6 kB | Adobe PDF | Ver/Abrir |
