Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44064
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Soares, Ana M. S. | por |
dc.contributor.author | Hungerford, Graham | por |
dc.contributor.author | Costa, Susana P. G. | por |
dc.contributor.author | Gonçalves, M. Sameiro T. | por |
dc.date.accessioned | 2017-01-02T10:14:55Z | - |
dc.date.available | 2017-01-02T10:14:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | A. M. S. Soares, G. Hungerford, S. P. G. Costa M. S. T. Gonçalves, “Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles”, Dyes and Pigments, 2017, 137, 91-100. | por |
dc.identifier.issn | 0143-7208 | por |
dc.identifier.uri | https://hdl.handle.net/1822/44064 | - |
dc.description.abstract | New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at position 2 of the heterocyclic system were used in the synthesis of ester conjugates of butyric acid. Photolysis at selected wavelengths in methanol/HEPES buffer (80:20) solutions, monitored by HPLC/UV and 1H NMR, produced the complete release of butyric acid. The shorter irradiation times for cleavage at longer wavelengths occurred for the conjugate with a 4-oxo-4H-benzopyran-2-yl substituent and thus (6-oxo-2-(4-oxo-4H-benzopyran-2-yl)-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl has potential as a candidate photosensitive moiety for butyric acid prodrugs. | por |
dc.description.sponsorship | Thanks are due to the Fundação para a Ciência e Tecnologia (FCT, Portugal) for financial support to the NMR portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho), FCT and FEDER (European Fund for Regional Development)-COMPETE-QREN-EU for financial support to the research centre CQ/UM [PEst-C/QUI/UI0686/2013 (FCOMP-01-0124-FEDER-022716)] and a PhD grant to A.M.S.S. (SFRH/BD/80813/2011) is also acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | PTNMR, Bruker Avance III 400-Univ. Minho | por |
dc.relation | [PEst-C/QUI/UI0686/2013 (FCOMP-01-0124-FEDER-022716) | por |
dc.relation | SFRH/BD/80813/2011 | por |
dc.rights | openAccess | por |
dc.subject | Prodrugs | por |
dc.subject | Coumarins | por |
dc.subject | Oxazoles | por |
dc.subject | Butyric acid | por |
dc.subject | Photocleavable protecting groups | por |
dc.subject | Photolysis | por |
dc.title | Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | info:eu-repo/semantics/acceptedVersion | por |
oaire.citationStartPage | 91 | por |
oaire.citationEndPage | 100 | por |
oaire.citationTitle | Dyes and Pigments | por |
oaire.citationVolume | 137 | por |
dc.identifier.doi | 10.1016/j.dyepig.2016.10.001 | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Dyes and Pigments | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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-MSTG-Final revised manuscript.pdf | 855,6 kB | Adobe PDF | Ver/Abrir |