Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40148

TitleHemispheric dorsolateral prefrontal cortex lateralization in the regulation of empathy for pain
Author(s)Rêgo, Gabriel G.
Lapenta, Olívia M.
Marques, Lucas Murrins
Costa, Thiago L.
Leite, Jorge
Carvalho, Sandra Conceição Ribeiro
Gonçalves, Óscar F.
Brunoni, Andre R.
Fregni, Felipe
Boggio, Paulo S.
KeywordsAdolescent
Adult
Affect
Arousal
Double-blind Method
Emotions
Female
Functional laterality
Humans
Male
Photic stimulation
Prefrontal cortex
Pupil
Transcranial direct current stimulation
Visual perception
Young adult
Empathy
Pain
Physical pain
Pain empathy
Emotion regulation
Dorsolateral prefrontal cortex
Pupil dilation
Issue date2015
PublisherElsevier
JournalNeuroscience letters
Abstract(s)The dorsolateral prefrontal cortex (DLPFC) is involved in the cognitive appraisal and modulation of the pain experience. In this sham-controlled study, with healthy volunteers, we used bi-hemispheric transcranial direct current stimulation (tDCS) over the DLPFC to assess emotional reactions elicited by pain observation. Left-cathodal/right-anodal tDCS decreased valence and arousal evaluations compared to other tDCS conditions. Compared to sham condition, both left-cathodal/right-anodal and left-anodal/right-cathodal tDCS decreased hostility, sadness and self-pain perception. These decreased sensations after both active tDCS suggest a common role for left and right DLPFC in personal distress modulation. However, the differences in arousal and valence evaluations point to distinct roles of lateralized DLPFC in cognitive empathy, probably through distinct emotion regulation mechanisms.
TypeArticle
URIhttp://hdl.handle.net/1822/40148
DOI10.1016/j.neulet.2015.03.042
ISSN0304-3940
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CIPsi - Artigos (Papers)

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