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https://hdl.handle.net/1822/30555
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mesquita, S. D. | por |
dc.contributor.author | Ferreira, A. C. | por |
dc.contributor.author | Falcão, A. M. | por |
dc.contributor.author | Souza, João Carlos Cruz | por |
dc.contributor.author | Oliveira, Tiago Gil | por |
dc.contributor.author | Correia-Neves, Margarida | por |
dc.contributor.author | Sousa, N. | por |
dc.contributor.author | Marques, F. | por |
dc.contributor.author | Palha, Joana Almeida | - |
dc.date.accessioned | 2014-10-17T14:24:06Z | - |
dc.date.available | 2014-10-17T14:24:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1350-9047 | por |
dc.identifier.uri | https://hdl.handle.net/1822/30555 | - |
dc.description.abstract | The production, accumulation and aggregation of amyloid beta (Aß) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aß aggregation. Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Aß1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons. Although Aß1-42 stimulation decreases the dehydrogenase activity and survival of wild-type astrocytes, astrocytes lacking the expression of Lcn2 are not affected. This protection results from a lower expression of the proapoptotic gene Bim and a decreased inflammatory response. Altogether, these findings show that Aß toxicity to astrocytes requires LCN2, which represents a novel mechanism to target when addressing AD.Cell Death and Differentiation advance online publication, 23 May 2014; doi:10.1038/cdd.2014.68. | por |
dc.description.sponsorship | We thank Dr. Ioannis Sotiropoulos for reagents and comments. Sandro Da Mesquita and Ana Catarina Ferreira are recipients of PhD fellowships and Fernanda Marques is recipient of a postdoctoral fellowship by the Fundacao para a Ciencia e Tecnologia (FCT, Portugal)/FEDER. This work was supported by a grant from FCT/FEDER (EXPL/NEUOSD/2196/2013). | por |
dc.language.iso | eng | por |
dc.publisher | Nature Publishing Group | por |
dc.rights | openAccess | por |
dc.title | Lipocalin 2 modulates the cellular response to amyloid beta | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | www.nature.com | por |
oaire.citationStartPage | 1588 | por |
oaire.citationEndPage | 1599 | por |
oaire.citationIssue | 10 | por |
oaire.citationTitle | Cell Death and Differentiation | por |
oaire.citationVolume | 21 | por |
dc.date.updated | 2014-07-10T14:42:42Z | - |
dc.identifier.doi | 10.1038/cdd.2014.68 | por |
dc.identifier.pmid | 24853299 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cell Death and Differentiation | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mesquita sd_cell death diff 2014 pp.pdf | 4,89 MB | Adobe PDF | Ver/Abrir |