Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/30555
Título: | Lipocalin 2 modulates the cellular response to amyloid beta |
Autor(es): | Mesquita, S. D. Ferreira, A. C. Falcão, A. M. Souza, João Carlos Cruz Oliveira, Tiago Gil Correia-Neves, Margarida Sousa, N. Marques, F. Palha, Joana Almeida |
Data: | 2014 |
Editora: | Nature Publishing Group |
Revista: | Cell Death and Differentiation |
Resumo(s): | The production, accumulation and aggregation of amyloid beta (Aß) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aß aggregation. Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Aß1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons. Although Aß1-42 stimulation decreases the dehydrogenase activity and survival of wild-type astrocytes, astrocytes lacking the expression of Lcn2 are not affected. This protection results from a lower expression of the proapoptotic gene Bim and a decreased inflammatory response. Altogether, these findings show that Aß toxicity to astrocytes requires LCN2, which represents a novel mechanism to target when addressing AD.Cell Death and Differentiation advance online publication, 23 May 2014; doi:10.1038/cdd.2014.68. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/30555 |
DOI: | 10.1038/cdd.2014.68 |
ISSN: | 1350-9047 |
Versão da editora: | www.nature.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mesquita sd_cell death diff 2014 pp.pdf | 4,89 MB | Adobe PDF | Ver/Abrir |