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TitleCracking the Toll-like receptor code in fungal infections
Author(s)Cunha, Cristina
Romani, Luigina
Carvalho, Agostinho
KeywordsFungal infections
Genetic susceptibility
Innate immunity
Toll-like receptors
Issue dateOct-2010
PublisherInforma Healthcare
JournalExpert Review of Anti-infective Therapy
Abstract(s)Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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