Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29617
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Cunha, Cristina | - |
dc.contributor.author | Romani, Luigina | - |
dc.contributor.author | Carvalho, Agostinho | - |
dc.date.accessioned | 2014-07-10T11:34:24Z | - |
dc.date.available | 2014-07-10T11:34:24Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 1478-7210 | por |
dc.identifier.issn | 1744-8336 | por |
dc.identifier.uri | https://hdl.handle.net/1822/29617 | - |
dc.description.abstract | Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections. | por |
dc.description.sponsorship | This work was supported by the Specific Targeted Research Projects SYBARIS (FP7-HEALTH-2009), contract number 242220, and by the Italian Project PRIN 2007KLCKP8_004. Cristina Cunha and Agostinho Carvalho were financially supported by fellowships from Fundacao para a Ciencia e Tecnologia, Portugal (contracts SFRH/BD/65962/2009 and SFRH/BPD/46292/2008, respectively). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | por |
dc.language.iso | eng | por |
dc.publisher | Informa Healthcare | por |
dc.rights | openAccess | por |
dc.subject | Fungal infections | por |
dc.subject | Genetic susceptibility | por |
dc.subject | Inflammation | por |
dc.subject | Innate immunity | por |
dc.subject | Toll-like receptors | por |
dc.title | Cracking the Toll-like receptor code in fungal infections | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.expert-reviews.com/doi/abs/10.1586/eri.10.93 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1121 | por |
oaire.citationEndPage | 1137 | por |
oaire.citationIssue | 10 | por |
oaire.citationTitle | Expert Review of Anti-infective Therapy | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2014-06-12T14:01:22Z | - |
dc.identifier.doi | 10.1586/eri.10.93 | - |
dc.identifier.pmid | 20954879 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Expert Review of Anti-infective Therapy | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cunha c_ expert rev anti infect ther 2010.pdf | 2,44 MB | Adobe PDF | Ver/Abrir |