Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/18639
Título: | Genetic susceptibility to aspergillosis in allogeneic stem-cell transplantation |
Autor(es): | Cunha, Cristina Rodrigues, Fernando José dos Santos Zelante, Teresa Aversa, Franco Romani, Luigina Carvalho, Agostinho |
Palavras-chave: | Aspergillosis Stem cell transplantation Polymorphism Susceptibility Toll-like receptor Th17 |
Data: | Abr-2011 |
Editora: | Informa Healthcare |
Revista: | Medical Mycology |
Resumo(s): | Invasive aspergillosis (IA) is a major threat to positive outcomes for allogeneic stem-cell transplantation (allo-SCT) patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop infection. Therefore, the traditional view of neutropenia as a key risk factor for aspergillosis needs to be accommodated within new conceptual advances on host immunity and its relationship to infection. Polymorphisms in innate immune genes, such as those encoding TLRs, cytokines and cytokine receptors, have recently been associated with susceptibility to IA in allo-SCT recipients. This suggests that understanding host-pathogen interactions at the level of host genetic susceptibility will allow the formulation of new targeted and patient-tailored antifungal therapeutics, including improved donor screening. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18639 |
DOI: | 10.3109/13693786.2010.508797 |
ISSN: | 1369-3786 |
Versão da editora: | http://informahealthcare.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Cunha C_Med Mycol-posp 2011.pdf | versão posprint | 612,07 kB | Adobe PDF | Ver/Abrir |