Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/18639

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dc.contributor.authorCunha, Cristina-
dc.contributor.authorRodrigues, Fernando José dos Santos-
dc.contributor.authorZelante, Teresa-
dc.contributor.authorAversa, Franco-
dc.contributor.authorRomani, Luigina-
dc.contributor.authorCarvalho, Agostinho-
dc.date.accessioned2012-04-16T14:50:45Z-
dc.date.available2012-04-16T14:50:45Z-
dc.date.issued2011-04-
dc.identifier.issn1369-3786por
dc.identifier.urihttp://hdl.handle.net/1822/18639-
dc.description.abstractInvasive aspergillosis (IA) is a major threat to positive outcomes for allogeneic stem-cell transplantation (allo-SCT) patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop infection. Therefore, the traditional view of neutropenia as a key risk factor for aspergillosis needs to be accommodated within new conceptual advances on host immunity and its relationship to infection. Polymorphisms in innate immune genes, such as those encoding TLRs, cytokines and cytokine receptors, have recently been associated with susceptibility to IA in allo-SCT recipients. This suggests that understanding host-pathogen interactions at the level of host genetic susceptibility will allow the formulation of new targeted and patient-tailored antifungal therapeutics, including improved donor screening.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/65962/2009, SFRH/BPD/46292/2008por
dc.description.sponsorshipSpecific Targeted Research Projects MANASP (LSHE-CT-2006), contract number 037899 (FP6), Italian Project PRIN2007KLCKP8_004.por
dc.language.isoengpor
dc.publisherInforma Healthcarepor
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/242220por
dc.rightsopenAccesspor
dc.subjectAspergillosispor
dc.subjectStem cell transplantationpor
dc.subjectPolymorphismpor
dc.subjectSusceptibilitypor
dc.subjectToll-like receptorpor
dc.subjectTh17por
dc.titleGenetic susceptibility to aspergillosis in allogeneic stem-cell transplantationpor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://informahealthcare.com/por
sdum.publicationstatuspublishedpor
oaire.citationStartPageS137por
oaire.citationEndPageS143por
oaire.citationIssueS1por
oaire.citationTitleMedical Mycologypor
oaire.citationVolume49por
dc.identifier.doi10.3109/13693786.2010.508797por
dc.identifier.pmid20718605por
dc.subject.wosScience & Technologypor
sdum.journalMedical Mycologypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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