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https://hdl.handle.net/1822/17432
Título: | Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia |
Autor(es): | Termini, Lara Filho, A. L. Maciag, Paulo Cesar Etlinger, Daniela Alves, Venâncio Avancini Ferreira Nonogaki, Suely Soares, Fernando Augusto Villa, Luisa Lina |
Palavras-chave: | Human papillomavirus Tissue Microarray Biomarker Cervical Neoplasia Superoxide Dismutase-2 |
Data: | Jul-2011 |
Editora: | IOS Press |
Revista: | Disease Markers |
Resumo(s): | Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer. Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO). Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining. Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease. |
Tipo: | Artigo |
Descrição: | We are grateful to Carlos Ferreira do Nascimento and Severino Ferreira from the Hospital A.C. Camargo for technical assistance. We would like to thank Dr. Enrique Boccardo, Dr. Ismar Haga and Dr. Ana Paula Lepique for critical review of the manuscript and Dr. Erico Tosoni Costa for assistance in figure preparation. |
URI: | https://hdl.handle.net/1822/17432 |
DOI: | 10.3233/DMA-2011-0784 |
ISSN: | 0278-0240 |
Versão da editora: | http://iospress.metapress.com/content/p719428q1x560042/ |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Termini L_Disease Markers 2011.pdf Acesso restrito! | Documento principal | 968,68 kB | Adobe PDF | Ver/Abrir |