Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/17432
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Termini, Lara | - |
dc.contributor.author | Filho, A. L. | - |
dc.contributor.author | Maciag, Paulo Cesar | - |
dc.contributor.author | Etlinger, Daniela | - |
dc.contributor.author | Alves, Venâncio Avancini Ferreira | - |
dc.contributor.author | Nonogaki, Suely | - |
dc.contributor.author | Soares, Fernando Augusto | - |
dc.contributor.author | Villa, Luisa Lina | - |
dc.date.accessioned | 2012-02-24T18:48:19Z | - |
dc.date.available | 2012-02-24T18:48:19Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0278-0240 | por |
dc.identifier.uri | https://hdl.handle.net/1822/17432 | - |
dc.description | We are grateful to Carlos Ferreira do Nascimento and Severino Ferreira from the Hospital A.C. Camargo for technical assistance. We would like to thank Dr. Enrique Boccardo, Dr. Ismar Haga and Dr. Ana Paula Lepique for critical review of the manuscript and Dr. Erico Tosoni Costa for assistance in figure preparation. | por |
dc.description.abstract | Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer. Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO). Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining. Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease. | por |
dc.description.sponsorship | Dr. Lara Termini was a Post-Doctoral fellow from Fundação de Amparo à Pesquisa do Estado de São Paulo (grant 05/57274-9). | por |
dc.language.iso | eng | por |
dc.publisher | IOS Press | por |
dc.rights | restrictedAccess | por |
dc.subject | Human papillomavirus | por |
dc.subject | Tissue Microarray | por |
dc.subject | Biomarker | por |
dc.subject | Cervical Neoplasia | por |
dc.subject | Superoxide Dismutase-2 | por |
dc.title | Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://iospress.metapress.com/content/p719428q1x560042/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 275 | por |
oaire.citationEndPage | 281 | por |
oaire.citationIssue | 6 | por |
oaire.citationTitle | Disease Markers | por |
oaire.citationVolume | 30 | por |
dc.identifier.doi | 10.3233/DMA-2011-0784 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Disease Markers | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Termini L_Disease Markers 2011.pdf Acesso restrito! | Documento principal | 968,68 kB | Adobe PDF | Ver/Abrir |