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https://hdl.handle.net/1822/42503| Título: | Functionalised collagen-MnO2 fibres inhibit oxidative-induced apoptosis in degenerated IVD |
| Autor(es): | Pereira, Diana Ribeiro Tapeinos, C. Oliveira, J. M. Reis, R. L. Pandit, A. |
| Palavras-chave: | Collagen IL1b IVD Manganese dioxide Nanoparticles ROS Scavenging effect |
| Data: | Jul-2016 |
| Editora: | AO Foundation |
| Citação: | Pereira D. R., Tapeinos C., Oliveira J. M., Reis R. L., Pandit A. Functionalised collagen-MnO2 fibres inhibit oxidative-induced apoptosis in degenerated IVD, European Cells & Materials, Vol. 31, Issue 1, pp. P50, 14732262, 2016 |
| Resumo(s): | Intervertebral disc cell apoptosis has been reported as the major factor responsible in promoting disc degeneration. In this study we hypothesize that collagen fibres with manganese dioxide (MnO2) nanoparticles (NPs) can increase oxygen levels by scavenging ROS species and converting it into byproducts. The specific objective of this study is to fabricate collagen fibres incorporating NPs (Fig. 1), with controlled degradability that are able to scavenge ROS species and generate O2 while inhibiting annulus fibrosus (AF) cell apoptosis under inflamed conditions. |
| Tipo: | Resumo em ata de conferência |
| URI: | https://hdl.handle.net/1822/42503 |
| ISSN: | 14732262 |
| Versão da editora: | http://www.ecmjournal.org/journal/supplements/vol031supp01/vol031supp01_P.htm |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 18776-Diana_Pereira.pdf | 1,05 MB | Adobe PDF | Ver/Abrir |
