Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91792
Título: | Challenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway |
Autor(es): | Sousa, Ana Margarida Pereira, Maria Olívia |
Palavras-chave: | Cystic fibrosis Drug efficacy pediction In vitro models |
Data: | Jun-2024 |
Editora: | Taylor & Francis |
Revista: | Expert Opinion on Drug Discovery |
Citação: | Sousa, Ana Margarida; Pereira, Maria Olívia, Challenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway. Expert Opinion on Drug Discovery, 19(6), 635-638, 2024 |
Resumo(s): | [Excerpt] Cystic fibrosis (CF) is a genetic disorder caused by a defect in the CF transmembrane conductance regulator gene, characterized by the accumulation of thick, sticky, and acidified sputum in the lungs. This abnormal buildup of sputum, rich in nutrients, and the defective mucociliary clearance render CF patients vulnerable to both acute and chronic bacterial infections of the airways. These infections lead to inflammation, declining lung function, respiratory failure, and premature death [1]. |
Tipo: | Editorial em revista |
URI: | https://hdl.handle.net/1822/91792 |
DOI: | 10.1080/17460441.2024.2350567 |
ISSN: | 1746-0441 |
Versão da editora: | https://www.tandfonline.com/journals/iedc20 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_57872_1.pdf | 490,07 kB | Adobe PDF | Ver/Abrir |