Challenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway

Abstract

[Excerpt] Cystic fibrosis (CF) is a genetic disorder caused by a defect in the CF transmembrane conductance regulator gene, characterized by the accumulation of thick, sticky, and acidified sputum in the lungs. This abnormal buildup of sputum, rich in nutrients, and the defective mucociliary clearance render CF patients vulnerable to both acute and chronic bacterial infections of the airways. These infections lead to inflammation, declining lung function, respiratory failure, and premature death [1].