Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87205
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Campo DC | Valor | Idioma |
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dc.contributor.author | Loureiro-Campos, Eduardo | por |
dc.contributor.author | Mateus-Pinheiro, António | por |
dc.contributor.author | Patrício, Patrícia | por |
dc.contributor.author | Cunha, Carina Isabel Soares | por |
dc.contributor.author | Silva, Joana | por |
dc.contributor.author | Sardinha, Vanessa Alexandra Morais | por |
dc.contributor.author | Pinheiro, Bárbara Filipa Mendes | por |
dc.contributor.author | Silveira-Rosa, Tiago | por |
dc.contributor.author | Domingues, Ana Verónica Mendes | por |
dc.contributor.author | Rodrigues, Ana João | por |
dc.contributor.author | Oliveira, João | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Alves, Nuno Dinis Lopes Oliveira | por |
dc.contributor.author | Pinto, Luísa | por |
dc.date.accessioned | 2023-11-09T16:45:36Z | - |
dc.date.available | 2023-11-09T16:45:36Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Loureiro-Campos, E., Mateus-Pinheiro, A., Patrício, P., Soares-Cunha, C., Silva, J., Sardinha, V. M., … Pinto, L. (2021, December 3). Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. eLife. eLife Sciences Publications, Ltd. http://doi.org/10.7554/elife.70685 | - |
dc.identifier.uri | https://hdl.handle.net/1822/87205 | - |
dc.description.abstract | The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early postnatal development until adulthood. AP2γ deficiency promotes downregulation of hippocampal glutamatergic neurogenesis, altering the ontogeny of emotional and memory behaviors associated with hippocampus formation. The impairments induced by AP2γ constitutive deletion since early development leads to an anxious-like phenotype and memory impairments as early as the juvenile phase. These behavioral impairments either persist from the juvenile phase to adulthood or emerge in adult mice with deficits in behavioral flexibility and object location recognition. Collectively, we observed a progressive and cumulative impact of constitutive AP2γ deficiency on the hippocampal glutamatergic neurogenic process, as well as alterations on limbic-cortical connectivity, together with functional behavioral impairments. The results herein presented demonstrate the modulatory role exerted by the AP2γ transcription factor and the relevance of hippocampal neurogenesis in the development of emotional states and memory processes. | por |
dc.description.sponsorship | We would like to acknowledge Dr. Hubert Schorle for providing the AP2γ mice line. ELC, AMP, PP, CSC, JS, TSR, BMP, AVD, JFO, NDA, and LP received fellowships from the Portuguese Foundation for Science and Technology (FCT) (IF/00328/2015 to JFO; 2020.02855.CEECIND to LP). This work was funded by FCT (IF/01079/2014, PTDC/MED-NEU/31417/2017 Grant to JFO), BIAL Foundation Grants (037/18 to JFO and 427/14 to LP), “la Caixa” Foundation (ID 100010434 to AJR), under the agreement LCF/PR/HR20/52400020), the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 101003187 to AJR), and Nature Research Award for Driving Global Impact - 2019 Brain Sciences (to LP). This was also co-funded by the Life and Health Sciences Research Institute (ICVS), and by FEDER, through the Competitiveness Internationalization Operational Program (POCI), and by National funds, through the Foundation for Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020. Moreover, this work has been funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI - Portuguese Platform of Bioimaging PPBI-POCI-01–0145-FEDER-022122; by National funds, through the Foundation for Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020. | por |
dc.language.iso | eng | por |
dc.publisher | eLife Sciences Publications | - |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.02855.CEECIND%2FCP1600%2FCT0006/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01079%2F2014%2FCP1212%2FCT0017/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-NEU%2F31417%2F2017/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/101003187/EU | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | - |
dc.rights | openAccess | por |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods | por |
dc.type | article | eng |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://elifesciences.org/articles/70685 | - |
oaire.citationVolume | 10 | por |
dc.identifier.doi | 10.7554/eLife.70685 | por |
dc.identifier.pmid | 34859784 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
sdum.journal | Elife | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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elife-70685-v2.pdf | 4,55 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons