Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/87082

TitleThe yeast protein kinase Sch9 functions as a central nutrient-responsive hub that calibrates metabolic and stress-related responses
Author(s)Caligaris, Marco
Marques, Maria Belém Sousa Sampaio
Hatakeyama, Riko
Pillet, Benjamin
Ludovico, Paula
De Virgilio, Claudio
Winderickx, Joris
Nicastro, Raffaele
KeywordsSch9
TORC1
SNF1
Pkh1
Pkh2
Pkh3
Pho85
Lipid
Stress
Longevity
Issue date26-Jul-2023
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
JournalJournal of Fungi
CitationCaligaris, M.; Sampaio-Marques, B.; Hatakeyama, R.; Pillet, B.; Ludovico, P.; De Virgilio, C.; Winderickx, J.; Nicastro, R. The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses. J. Fungi 2023, 9, 787. https://doi.org/10.3390/jof9080787
Abstract(s)Yeast cells are equipped with different nutrient signaling pathways that enable them to sense the availability of various nutrients and adjust metabolism and growth accordingly. These pathways are part of an intricate network since most of them are cross-regulated and subject to feedback regulation at different levels. In yeast, a central role is played by Sch9, a protein kinase that functions as a proximal effector of the conserved growth-regulatory TORC1 complex to mediate information on the availability of free amino acids. However, recent studies established that Sch9 is more than a TORC1-effector as its activity is tuned by several other kinases. This allows Sch9 to function as an integrator that aligns different input signals to achieve accuracy in metabolic responses and stress-related molecular adaptations. In this review, we highlight the latest findings on the structure and regulation of Sch9, as well as its role as a nutrient-responsive hub that impacts on growth and longevity of yeast cells. Given that most key players impinging on Sch9 are well-conserved, we also discuss how studies on Sch9 can be instrumental to further elucidate mechanisms underpinning healthy aging in mammalians.
TypeArticle
URIhttps://hdl.handle.net/1822/87082
DOI10.3390/jof9080787
e-ISSN2309-608X
Publisher versionhttps://www.mdpi.com/2309-608X/9/8/787
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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