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TitleExploring the diversity of visceral, subcutaneous and perivascular adipose tissue in a vascular surgery population
Author(s)Ferreira, Joana
Afonso, Julieta Alexandra Pereira
Carneiro, Alexandre Lima
Vila, Isabel
Cunha, Cristina
Roque, Susana
Silva, Cristina
Mesquita, Amílcar
Cotter, Jorge
Correia-Neves, M
Mansilha, Armando
Longatto, Adhemar
Cunha, Pedro
KeywordsAdipose tissue
Cardiovascular risk factors
Angiotensin-converting-enzyme inhibitors
Angiotensin receptor antagonist
Issue date25-Jun-2023
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
JournalJournal of Cardiovascular Development and Disease
CitationFerreira, J.; Afonso, J.; Carneiro, A.L.; Vila, I.; Cunha, C.; Roque, S.; Silva, C.; Mesquita, A.; Cotter, J.; Correia-Neves, M.; et al. Exploring the Diversity of Visceral, Subcutaneous and Perivascular Adipose Tissue in a Vascular Surgery Population. J. Cardiovasc. Dev. Dis. 2023, 10, 271.
Abstract(s)The prevalence of obesity has doubled, with a concomitant increase in cardiovascular disease. This study aimed to compare the characteristics of visceral, subcutaneous and peri-aortic adipose tissue determined with computed tomography (CT) scans and to correlate them with cardiovascular risk factors, anthropometric measures and medication. An observational and prospective study was conducted, and 177 subjects were included. Peri-aortic adipose tissue had the highest density, while the subcutaneous adipose tissue had the lowest. The density of subcutaneous adipose tissue differs from the density of visceral (p = 0.00) and peri-aortic adipose tissue (p = 0.00). Smokers/ex-smokers had a lower area (p = 0.00) and density (p = 0.02) of subcutaneous adipose tissue. Multiple linear regression analysis showed that sex was a predictor of subcutaneous adipose tissue area (β = −0.27, t = −3.12, p = 0.00) but smoking habits were not. After controlling for sex, we found that the association between smokers/ex-smokers and area of subcutaneous adipose tissue was lost, but the association with density persisted. Patients with hypertension had a higher visceral adipose tissue area, and this relationship was maintained even after adjusting for gender. Peri-aortic adipose tissue is similar to visceral and distinct from subcutaneous adipose tissue. Cardiovascular risk factors have different influences in distinct adipose compartments.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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