Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/8646| Título: | Synthesis and antitumour evaluation of benzopsoralen analogues |
| Autor(es): | Oliveira, Ana M. A. G. Campos, Ana M. F. Oliveira Rodrigues, Lígia M. Raposo, M. Manuela M. Machado, António E. H. Nascimento, Maria São José Nazareth, N. Pinto, Madalena |
| Palavras-chave: | Psoralens Xanthen-9-one Carbazole Antitumour Coumarin |
| Data: | Mai-2007 |
| Editora: | Wiley |
| Revista: | Chemistry & Biodiversity |
| Citação: | Oliveira, A. . ., Oliveira-Campos, A. ., Rodrigues, L., Raposo, M. ., Machado, A. ., Nascimento, M. ., Nazareth, N. and Pinto, M. (2007), Synthesis and Antitumor Evaluation of Benzopsoralen Analogues. Chemistry & Biodiversity, 4: 980-990. https://doi.org/10.1002/cbdv.200790089 |
| Resumo(s): | The synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of the final products was evaluated and is discussed in terms of the 3D-geometry and electronic density distribution. The compounds showing significant biological activity in this study were those having angular structures. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/8646 |
| DOI: | 10.1002/cbdv.200790089 |
| ISSN: | 1612-1872 |
| e-ISSN: | 1612-1880 |
| Versão da editora: | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Xantonas.pdf | Documento Principal | 190,67 kB | Adobe PDF | Ver/Abrir |
