Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/8646

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dc.contributor.authorOliveira, Ana M. A. G.-
dc.contributor.authorCampos, Ana M. F. Oliveira-
dc.contributor.authorRodrigues, Lígia M.-
dc.contributor.authorRaposo, M. Manuela M.-
dc.contributor.authorMachado, António E. H.-
dc.contributor.authorNascimento, Maria São José-
dc.contributor.authorNazareth, N.-
dc.contributor.authorPinto, Madalena-
dc.date.accessioned2009-01-22T15:48:18Z-
dc.date.available2009-01-22T15:48:18Z-
dc.date.issued2007-05-
dc.identifier.citation"Chemistry & Biodiversity." ISSN 1612-1872. 4:5 (May 2007) 980-990.en
dc.identifier.issn1612-1872en
dc.identifier.issn1612-1880en
dc.identifier.urihttp://hdl.handle.net/1822/8646-
dc.description.abstractThe synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of the final products was evaluated and is discussed in terms of the 3D-geometry and electronic density distribution. The compounds showing significant biological activity in this study were those having angular structures.en
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT) - I&D226/94, POCTI-SFA-3-686), PRAXIS XXI/BD/19707/99)en
dc.description.sponsorshipFEDERen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)en
dc.description.sponsorshipConselho Nacional do Desenvolvimento Científico eTecnológico - Brasil (CNPq)en
dc.language.isoengen
dc.publisherWileyen
dc.rightsopenAccessen
dc.subjectPsoralensen
dc.subjectXanthen-9-oneen
dc.subjectCarbazoleen
dc.subjectAntitumouren
dc.subjectCoumarinen
dc.titleSynthesis and antitumour evaluation of benzopsoralen analoguesen
dc.typearticlepor
dc.peerreviewedyesen
dc.relation.publisherversionwww.interscience.wiley.comen
sdum.number5en
sdum.pagination980-990en
sdum.publicationstatuspublisheden
sdum.volume4en
oaire.citationStartPage980por
oaire.citationEndPage990por
oaire.citationIssue5por
oaire.citationVolume4por
dc.identifier.doi10.1002/cbdv.200790089por
dc.identifier.pmid17510993por
dc.subject.wosScience & Technologypor
sdum.journalChemistry & Biodiversitypor
Appears in Collections:CDQuim - Artigos (Papers)

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