Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/8646
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Oliveira, Ana M. A. G. | - |
dc.contributor.author | Campos, Ana M. F. Oliveira | - |
dc.contributor.author | Rodrigues, Lígia M. | - |
dc.contributor.author | Raposo, M. Manuela M. | - |
dc.contributor.author | Machado, António E. H. | - |
dc.contributor.author | Nascimento, Maria São José | - |
dc.contributor.author | Nazareth, N. | - |
dc.contributor.author | Pinto, Madalena | - |
dc.date.accessioned | 2009-01-22T15:48:18Z | - |
dc.date.available | 2009-01-22T15:48:18Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | Oliveira, A. . ., Oliveira-Campos, A. ., Rodrigues, L., Raposo, M. ., Machado, A. ., Nascimento, M. ., Nazareth, N. and Pinto, M. (2007), Synthesis and Antitumor Evaluation of Benzopsoralen Analogues. Chemistry & Biodiversity, 4: 980-990. https://doi.org/10.1002/cbdv.200790089 | en |
dc.identifier.issn | 1612-1872 | en |
dc.identifier.uri | https://hdl.handle.net/1822/8646 | - |
dc.description.abstract | The synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of the final products was evaluated and is discussed in terms of the 3D-geometry and electronic density distribution. The compounds showing significant biological activity in this study were those having angular structures. | en |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (FCT) - I&D226/94, POCTI-SFA-3-686), PRAXIS XXI/BD/19707/99) | en |
dc.description.sponsorship | FEDER | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) | en |
dc.description.sponsorship | Conselho Nacional do Desenvolvimento Científico eTecnológico - Brasil (CNPq) | en |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.relation | info:eu-repo/grantAgreement/FCT/POCTI/PRAXIS XXI%2FBD%2F19707%2F99/PT | - |
dc.rights | openAccess | en |
dc.subject | Psoralens | en |
dc.subject | Xanthen-9-one | en |
dc.subject | Carbazole | en |
dc.subject | Antitumour | en |
dc.subject | Coumarin | en |
dc.title | Synthesis and antitumour evaluation of benzopsoralen analogues | en |
dc.type | article | por |
dc.peerreviewed | yes | en |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089 | en |
sdum.number | 5 | en |
sdum.pagination | 980-990 | en |
sdum.publicationstatus | published | en |
sdum.volume | 4 | en |
oaire.citationStartPage | 980 | por |
oaire.citationEndPage | 990 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 4 | por |
dc.identifier.eissn | 1612-1880 | - |
dc.identifier.doi | 10.1002/cbdv.200790089 | por |
dc.identifier.pmid | 17510993 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Chemistry & Biodiversity | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Xantonas.pdf | Documento Principal | 190,67 kB | Adobe PDF | Ver/Abrir |