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https://hdl.handle.net/1822/7917
Título: | MRI assessment of superior temporal gyrus in Williams syndrome |
Autor(es): | Sampaio, Adriana Sousa, Nuno Férnandez, Montse Vasconcelos, Cristiana Shenton, Martha E. Gonçalves, Óscar F. |
Palavras-chave: | Williams syndrome STG Language Neurodevelopment |
Data: | 6-Jun-2008 |
Editora: | Lippincott, Williams & Wilkins |
Revista: | Cognitive and Behavioral Neurology |
Resumo(s): | Objective: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. Background: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is implicated in linguistic processing and is a highly lateralized brain region. Method: Here, we examined STG volumes and asymmetry of STG in WS patients and in age-matched controls. We also correlated volume of STG with a subset of verbal measures. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5-mm contiguous slices, and were used to measure whole gray matter, white matter, and cerebrospinal fluid volumes, and also STG volume. Results: Results revealed significantly reduced intracranial volume in WS patients, compared with controls. Right and left STG were also significantly smaller in WS patients. In addition, compared with normal controls, a lack of normal left >right STG asymmetry was evident in WS. Also of note was the finding that, in contrast to controls, WS patients did not reveal a positive correlation between verbal intelligence quotient and left STG volume, which further suggests a disruption in this region of the brain. Conclusions: In conclusion, atypical patterns of asymmetry and reduced STG volume in WS were observed, which may, in part, contribute to some of the linguistic impairments found in this cohort of WS patients. |
Tipo: | Artigo |
Descrição: | Prova tipográfica (In Press) |
URI: | https://hdl.handle.net/1822/7917 |
DOI: | 10.1097/WNN.0b013e31817720e4 |
ISSN: | 1543-3633 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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WNN_200121.pdf | 285,07 kB | Adobe PDF | Ver/Abrir |