Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/76772

TitleAdvances in Candida sp. Biofilm Mannans
Author(s)Romo, Jesus A.
Rodrigues, Maria Elisa Costa
Fernandes, Liliana Sousa
Papp, Csaba
Gácser, Attila
Rodrigues, Célia Fortuna
KeywordsCandida
Mannan
B-1,3 glucans
Biofilm
Matrix
Pathogenesis
Cell wall
NAC
Issue dateAug-2019
PublisherNova Science Publishers
CitationRomo, Jesus A.; Rodrigues, M. Elisa; Fernandes, L.; Papp, Csaba; Gácser, Attila; Rodrigues, Célia F., Advances in Candida sp. Biofilm Mannans. In Leon V. Berhardt, Advances in Medicine and Biology, Vol. 151(3), Nova Science Publishers, 2019. ISBN: 978-1-53616-352-0, 99-128
Abstract(s)Candida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to non-albicans Candida (NAC) species has significantly increased. Candida species have several virulence factors, such as hyphal growth, secretion of hydrolases, and the ability to form biofilms. Biofilm formation is considered one of the main virulence factors of C. albicans. Biofilm production can occur on the host mucosa and on the surface of medical indwelling devices and includes a self-produced polymeric matrix that encloses fungal micro-colonies in a complex structure. The main components of the biofilm matrix are polysaccharides (e.g. B-1,3 glucans and mannans), but proteins, DNA and lipids (e.g. ergosterol) can also be found in variable amounts. In this chapter, we will discuss the role of mannans within Candida biofilms. Additionally, the role of Candida biofilms in fungal structure, pathogenesis, and resistance will also be addressed.
TypeBook part
URIhttps://hdl.handle.net/1822/76772
ISBN978-1-53616-352-0
Publisher versionhttps://novapublishers.com/shop/advances-in-medicine-and-biology-volume-151/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Livros e Capítulos de Livros / Books and Book Chapters

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