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TitleConotoxin loaded dextran microgel particles alleviate effects of spinal cord injury by inhibiting neuronal excitotoxicity
Author(s)Zhao, X.
Jin, L.
Zhu, Z.
Lu, H.
Shi, H.
Zhong, Q.
Oliveira, J. M.
Reis, R. L.
Gao, C.
Zhengwei, M.
Spinal cord injury
Motor functional recovery
Issue dateJun-2021
JournalApplied Materials Today
CitationZhao X., Jin L., Zhu Z., Lu H., Shi H., Zhong Q., Oliveira J. M., Reis R. L., Gao C., Zhengwei M. Conotoxin loaded dextran microgel particles alleviate effects of spinal cord injury by inhibiting neuronal excitotoxicity, Applied Materials Today, Vol. 23, pp. 101064, doi:10.1016/j.apmt.2021.101064, 2021
Abstract(s)Spinal cord injury (SCI) is a severe refractory disabling condition accompanied by complicated patholog- ical processes, such as excessive glutamate release in the extracellular environment and massive influx of Ca 2 + into cells. Dextran can absorb extracellular glutamate and Ca 2 + to attenuate persistent excita- tory processes that are detrimental to normal cells. Calcium channel inhibitors reduce the influx of Ca 2 + , thereby relieving subsequent cytotoxicity such as mitochondria damage. Here, a bifunctional microgel was designed for delivering GVIA, an N-type calcium ion channel blocker, to achieve a combinational therapy of simultaneously reducing the Ca 2 + and glutamate concentrations in extracellular environment and in- hibiting excess Ca 2 + influx. The obtained dextran microgels could effectively encapsulate GVIA peptide, which displayed sustained release. Microgels loaded with GVIA (DexGVIA) played an excellent neuropro- tective role by relieving the influx of Ca 2 + in vitro . DexGVIA also exhibited promising therapeutic effect in vivo via reducing the lesion cavity, saving neurons and gliacytes from the injury, and improving con- tinuity and integrity of the spinal cord, thus distinctly accelerated motor functional recovery of SCI rats. Our work provided a combinational strategy against excitotoxicity, with potential applications not only in SCI, but also in other pathologically similar conditions of the central nervous system.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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