Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73988
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Campo DC | Valor | Idioma |
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dc.contributor.author | Zhao, X. | por |
dc.contributor.author | Jin, L. | por |
dc.contributor.author | Zhu, Z. | por |
dc.contributor.author | Lu, H. | por |
dc.contributor.author | Shi, H. | por |
dc.contributor.author | Zhong, Q. | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gao, C. | por |
dc.contributor.author | Zhengwei, M. | por |
dc.date.accessioned | 2021-09-10T08:55:13Z | - |
dc.date.issued | 2021-06 | - |
dc.date.submitted | 2021-03 | - |
dc.identifier.citation | Zhao X., Jin L., Zhu Z., Lu H., Shi H., Zhong Q., Oliveira J. M., Reis R. L., Gao C., Zhengwei M. Conotoxin loaded dextran microgel particles alleviate effects of spinal cord injury by inhibiting neuronal excitotoxicity, Applied Materials Today, Vol. 23, pp. 101064, doi:10.1016/j.apmt.2021.101064, 2021 | por |
dc.identifier.issn | 2352-9407 | por |
dc.identifier.uri | https://hdl.handle.net/1822/73988 | - |
dc.description.abstract | Spinal cord injury (SCI) is a severe refractory disabling condition accompanied by complicated patholog- ical processes, such as excessive glutamate release in the extracellular environment and massive influx of Ca 2 + into cells. Dextran can absorb extracellular glutamate and Ca 2 + to attenuate persistent excita- tory processes that are detrimental to normal cells. Calcium channel inhibitors reduce the influx of Ca 2 + , thereby relieving subsequent cytotoxicity such as mitochondria damage. Here, a bifunctional microgel was designed for delivering GVIA, an N-type calcium ion channel blocker, to achieve a combinational therapy of simultaneously reducing the Ca 2 + and glutamate concentrations in extracellular environment and in- hibiting excess Ca 2 + influx. The obtained dextran microgels could effectively encapsulate GVIA peptide, which displayed sustained release. Microgels loaded with GVIA (DexGVIA) played an excellent neuropro- tective role by relieving the influx of Ca 2 + in vitro . DexGVIA also exhibited promising therapeutic effect in vivo via reducing the lesion cavity, saving neurons and gliacytes from the injury, and improving con- tinuity and integrity of the spinal cord, thus distinctly accelerated motor functional recovery of SCI rats. Our work provided a combinational strategy against excitotoxicity, with potential applications not only in SCI, but also in other pathologically similar conditions of the central nervous system. | por |
dc.description.sponsorship | National Key Research and Development Program of China (2016YFE0132700), the National Natural Science Foundation of China (51822306), Zhejiang Provincial Natural Science Foundation of China (LY20H060008), Science Technology Department Project of Zhejiang Province (2020C03042), the Fundamental Research Funds for the Central Universities of China and Zhejiang University Global Partnership Fund (100000-11320) | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Dextran | por |
dc.subject | Microgel | por |
dc.subject | Spinal cord injury | por |
dc.subject | Excitotoxicity | por |
dc.subject | GVIA | por |
dc.subject | Motor functional recovery | por |
dc.title | Conotoxin loaded dextran microgel particles alleviate effects of spinal cord injury by inhibiting neuronal excitotoxicity | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2352940721001293 | por |
dc.comments | http://3bs.uminho.pt/node/20531 | por |
oaire.citationVolume | 23 | por |
dc.date.updated | 2021-09-10T08:16:05Z | - |
dc.identifier.doi | 10.1016/j.apmt.2021.101064 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Applied Materials Today | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20531-1-s20-s2352940721001293-main.pdf Acesso restrito! | 3,72 MB | Adobe PDF | Ver/Abrir |