Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/69873

TitleCOVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions?
Author(s)Arastehfar, Amir
Carvalho, Agostinho
Nguyen, M. Hong
Hedayati, Mohammad Taghi
Netea, Mihai G.
Perlin, David S.
Hoenigl, Martin
Keywordscandidemia
candiduria
oral candidiasis
mycobiome
COVID-19
Issue date2020
PublisherMultidisciplinary Digital Publishing Institute
JournalJournal of Fungi
CitationArastehfar, A.; Carvalho, A.; Nguyen, M.H.; Hedayati, M.T.; Netea, M.G.; Perlin, D.S.; Hoenigl, M. COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions? J. Fungi 2020, 6, 211. https://doi.org/10.3390/jof6040211
Abstract(s)The recent global pandemic of COVID-19 has predisposed a relatively high number of patients to acute respiratory distress syndrome (ARDS), which carries a risk of developing super-infections. <i>Candida</i> species are major constituents of the human mycobiome and the main cause of invasive fungal infections, with a high mortality rate. Invasive yeast infections (IYIs) are increasingly recognized as s complication of severe COVID-19. Despite the marked immune dysregulation in COVID-19, no prominent defects have been reported in immune cells that are critically required for immunity to <i>Candida</i>. This suggests that relevant clinical factors, including prolonged ICU stays, central venous catheters, and broad-spectrum antibiotic use, may be key factors causing COVID-19 patients to develop IYIs. Although data on the comparative performance of diagnostic tools are often lacking in COVID-19 patients, a combination of serological and molecular techniques may present a promising option for the identification of IYIs. Clinical awareness and screening are needed, as IYIs are difficult to diagnose, particularly in the setting of severe COVID-19. Echinocandins and azoles are the primary antifungal used to treat IYIs, yet the therapeutic failures exerted by multidrug-resistant <i>Candida</i> spp. such as <i>C. auris</i> and <i>C. glabrata</i> call for the development of new antifungal drugs with novel mechanisms of action.
TypeArticle
URIhttps://hdl.handle.net/1822/69873
DOI10.3390/jof6040211
e-ISSN2309-608X
Publisher versionhttps://www.mdpi.com/2309-608X/6/4/211
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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