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https://hdl.handle.net/1822/67945| Título: | Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies |
| Autor(es): | Service, Susan DeYoung, Joseph Karayiorgou, Maria Roos, J. Louw Pretorious, Herman Bedoya, Gabriel Ospina, Jorge Ruiz-Linares, Andres Macedo, António Palha, Joana Almeida Heutink, Peter Aulchenko, Yurii Oostra, Ben van Duijn, Cornelia Jarvelin, Marjo-Riitta Varilo, Teppo Peddle, Lynette Rahman, Proton Piras, Giovanna Monne, Maria Murray, Sarah Galver, Luana Peltonen, Leena Sabatti, Chiara Collins, Andrew Freimer, Nelson |
| Palavras-chave: | Chromosomes, Human, Pair 22 Humans Polymorphism, Single Nucleotide Genetics, Population Genome, Human Linkage Disequilibrium |
| Data: | Abr-2006 |
| Editora: | Nature Research |
| Revista: | Nature Genetics |
| Citação: | Service, S., DeYoung, J., Karayiorgou, M., Roos, J. L., et. al. (2006). Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nature genetics, 38(5), 556-560 |
| Resumo(s): | The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/67945 |
| DOI: | 10.1038/ng1770 |
| ISSN: | 1061-4036 |
| e-ISSN: | 1546-1718 |
| Versão da editora: | https://www.nature.com/articles/ng1770 |
| Arbitragem científica: | yes |
| Acesso: | Acesso restrito autor |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| service2006.pdf Acesso restrito! | 368,34 kB | Adobe PDF | Ver/Abrir |
