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https://hdl.handle.net/1822/67734
Título: | The thymus as a target for mycobacterial infections |
Autor(es): | Nobrega, Claudia Cardona, Pere-Joan Roque, Susana Pinto do Ó, Perpétua Appelberg, Rui Correia-Neves, M. |
Palavras-chave: | Animals Colony Count, Microbial Female Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mycobacterium Infections Mycobacterium avium Mycobacterium bovis Mycobacterium tuberculosis Organ Specificity T-Lymphocytes Thymus Gland BCG thymus |
Data: | 2007 |
Editora: | Elsevier 1 |
Revista: | Microbes and Infection |
Citação: | Nobrega, C., Cardona, P. J., Roque, S., et. al.(2007). The thymus as a target for mycobacterial infections. Microbes and infection, 9(14-15), 1521-1529 |
Resumo(s): | Mycobacterial infections are among the major health threats worldwide. Ability to fight these infections depends on the host's immune response, particularly on macrophages and T lymphocytes produced by the thymus. Using the mouse as a model, and two different routes of infection (aerogenic or intravenous), we show that the thymus is consistently colonized by Mycobacterium tuberculosis, Mycobacterium avium or Mycobacterium bovis BCG. When compared to organs such as the liver and spleen, the bacterial load reaches a plateau at later time-points after infection. Moreover, in contrast with organs such as the spleen and the lung no granuloma were found in the thymus of mice infected with M. tuberculosis or M. avium. Since T cell differentiation depends, to a large extent, on the antigens encountered within the thymus, infection of this organ might alter the host's immune response to infection. Therefore, from now on, the thymus should be considered in studies addressing the immune response to mycobacterial infection. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67734 |
DOI: | 10.1016/j.micinf.2007.08.006 |
ISSN: | 1286-4579 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1286457907002754 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nobrega2007.pdf Acesso restrito! | 2,02 MB | Adobe PDF | Ver/Abrir |