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https://hdl.handle.net/1822/67649
Título: | Up-regulation of plasminogen activator inhibitor-2 is associated with high-risk HPV and grade of cervical lesion at baseline but does not predict outcomes of high-risk HPV infections or incident CIN |
Autor(es): | Syrjänen, Stina Naud, Paulo Sarian, Luis Derchain, Sophie Roteli-Martins, Cecilia Longatto, Adhemar Tatti, Silvio Branca, Margerita Erzen, Mojca Hammes, Luciano S. Costa, Silvano Syrjänen, Kari |
Palavras-chave: | Biomarkers, Tumor Cell Nucleus Cervical Intraepithelial Neoplasia DNA, Viral Disease Progression Female Humans Immunohistochemistry Papillomaviridae Papillomavirus Infections Plasminogen Activator Inhibitor Type 2 Predictive Value of Tests Up-Regulation Uterine Cervical Neoplasms Viral Load High-risk human papillomavirus HPV PAI-2 Serpin-B2 Cytoplasmic Nuclear CIN Baseline Viral outcomes Longitudinal predictive values Surrogate end points |
Data: | Dez-2009 |
Editora: | Oxford University Press |
Revista: | American Journal of Clinical Pathology |
Resumo(s): | Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells. Our objective was to assess whether the pRb-mediated HPV-suppressive effect of PAI-2 in cancer cell lines has implications in the outcome of HPV infections. Cervical biopsy specimens from 225 women were analyzed for PAI-2 expression to assess its value as a predictor of cervical intraepithelial neoplasia (CIN) grade, high-risk (HR) HPV at baseline, outcomes of HR-HPV infections, and the development of incident CIN. PAI-2 expression increased in parallel with lesion grade. Nuclear PAI-2 expression was significantly related to HR-HPV detection and had a linear relationship with HR-HPV load. PAI-2 expression was of no value in predicting the outcomes of HR-HPV infections. The same was true for PAI-2 as a predictor of surrogate end points (incident CIN 1+, CIN 2+) of progressive disease. PAI-2 expression is up-regulated on transition from CIN 2 to CIN 3. The HR-HPV suppressive effects of PAI-2 were not related to more favorable outcomes of HR-HPV infections or lower risk of disease progression to CIN. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67649 |
DOI: | 10.1309/AJCPQQ07WUTZUTES |
ISSN: | 1943-7722 |
e-ISSN: | 0002-9173 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Syrjanen-2009-Up-regulation-of-plasminogen-activa.pdf Acesso restrito! | 456,25 kB | Adobe PDF | Ver/Abrir |