Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/67649

TitleUp-regulation of plasminogen activator inhibitor-2 is associated with high-risk HPV and grade of cervical lesion at baseline but does not predict outcomes of high-risk HPV infections or incident CIN
Author(s)Syrjänen, Stina
Naud, Paulo
Sarian, Luis
Derchain, Sophie
Roteli-Martins, Cecilia
Longatto, Adhemar
Tatti, Silvio
Branca, Margerita
Erzen, Mojca
Hammes, Luciano S.
Costa, Silvano
Syrjänen, Kari
KeywordsBiomarkers, Tumor
Cell Nucleus
Cervical Intraepithelial Neoplasia
DNA, Viral
Disease Progression
Female
Humans
Immunohistochemistry
Papillomaviridae
Papillomavirus Infections
Plasminogen Activator Inhibitor Type 2
Predictive Value of Tests
Up-Regulation
Uterine Cervical Neoplasms
Viral Load
High-risk human papillomavirus
HPV
PAI-2
Serpin-B2
Cytoplasmic
Nuclear
CIN
Baseline
Viral outcomes
Longitudinal predictive values
Surrogate end points
Issue dateDec-2009
PublisherOxford University Press
JournalAmerican Journal of Clinical Pathology
Abstract(s)Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells. Our objective was to assess whether the pRb-mediated HPV-suppressive effect of PAI-2 in cancer cell lines has implications in the outcome of HPV infections. Cervical biopsy specimens from 225 women were analyzed for PAI-2 expression to assess its value as a predictor of cervical intraepithelial neoplasia (CIN) grade, high-risk (HR) HPV at baseline, outcomes of HR-HPV infections, and the development of incident CIN. PAI-2 expression increased in parallel with lesion grade. Nuclear PAI-2 expression was significantly related to HR-HPV detection and had a linear relationship with HR-HPV load. PAI-2 expression was of no value in predicting the outcomes of HR-HPV infections. The same was true for PAI-2 as a predictor of surrogate end points (incident CIN 1+, CIN 2+) of progressive disease. PAI-2 expression is up-regulated on transition from CIN 2 to CIN 3. The HR-HPV suppressive effects of PAI-2 were not related to more favorable outcomes of HR-HPV infections or lower risk of disease progression to CIN.
TypeArticle
URIhttps://hdl.handle.net/1822/67649
DOI10.1309/AJCPQQ07WUTZUTES
ISSN1943-7722
e-ISSN0002-9173
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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