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https://hdl.handle.net/1822/67608
Título: | The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer |
Autor(es): | Pinheiro, Céline Longatto, Adhemar Simões, Kleber Jacob, Carlos Eduardo Bresciani, Cláudio José Caldas Zilberstein, Bruno Cecconello, Ivan Alves, Venâncio Avancini Ferreira Schmitt, Fernando Baltazar, Fátima |
Palavras-chave: | Basigin Female Humans Immunohistochemistry Lymphatic metastasis Male Middle aged Monocarboxylic acid transporters Neoplasm proteins Prognosis Stomach neoplasms CD147/EMMPRIN Monocarboxylate transporters Gastric cancer |
Data: | Set-2009 |
Editora: | Elsevier 1 |
Revista: | European Journal of Cancer |
Resumo(s): | The aim of the present work was to assess the role of monocarboxylate transporters (MCTs), namely MCT1 and MCT4 as well as MCT/CD147 co-expression in gastric tissues and evaluate their clinico-pathological significance in gastric carcinoma. For that, we analysed the immunohistochemical expression of MCT1, MCT4 and CD147, in a large series of gastric samples, including non-neoplastic, tumour and metastatic tissues. A significant decrease in MCT4 plasma membrane expression was observed from non-neoplastic to gastric primary malignant tissues and to lymph-node metastasis and both MCT1 and MCT4 correlated with CD147. Importantly, both MCT4 and CD147 were more frequently expressed in Lauren's intestinal-type tumours and MCT1/CD147 co-expression was associated with advanced gastric carcinoma, Lauren's intestinal type, TNM staging and lymph-node metastasis. Our results showed that the prognostic value of CD147 was associated with MCT1 co-expression in gastric cancer cells, supporting the view that CD147 plasma membrane activity is dependent on MCT co-expression. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67608 |
DOI: | 10.1016/j.ejca.2009.06.018 |
ISSN: | 0959-8049 |
e-ISSN: | 1879-0852 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0959804909004857 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Pinheiro-2009-The-prognostic-value-of-cd-emmprin-.pdf Acesso restrito! | 185,3 kB | Adobe PDF | Ver/Abrir |