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https://hdl.handle.net/1822/67537
Título: | The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance |
Autor(es): | Dinamarco, Taísa Magnani Pimentel, Bárbara de Castro Figueiredo Savoldi, Marcela Malavazi, Iran Soriani, Frederico Marianetti Uyemura, Sérgio Akira Ludovico, Paula Goldman, Maria Helena S. Goldman, Gustavo Henrique |
Palavras-chave: | Apoptosis Inducing Factor Aspergillus nidulans Electron Transport Complex I Farnesol Fungal Proteins Mitochondria Reactive Oxygen Species NADH-ubiquinone oxidoreductases Apopotosis inducing factor |
Data: | Dez-2010 |
Editora: | Elsevier 1 |
Revista: | Fungal Genetics and Biology |
Citação: | Dinamarco, T. M., Pimentel, B. D. C. F., Savoldi, M., et. al. (2010). The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. Fungal Genetics and Biology, 47(12), 1055-1069 |
Resumo(s): | Farnesol (FOH) is a nonsterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, a catabolite of the cholesterol biosynthetic pathway. These isoprenoids inhibit proliferation and induce apoptosis. Here, we show that Aspergillus nidulans AifA encoding the apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase plays a role in the function of the mitochondrial Complex I. Additionally, we demonstrated that ndeA-B and ndiA encode external and internal alternative NADH dehydrogenases, respectively, that have a function in FOH resistance. When exposed to FOH, the ΔaifA and ΔndeA strains have increased ROS production while ΔndeB, ΔndeA ΔndeB, and ΔndiA mutant strains showed the same ROS accumulation than in the absence of FOH. We observed several compensatory mechanisms affecting the differential survival of these mutants to FOH. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67537 |
DOI: | 10.1016/j.fgb.2010.07.006 |
ISSN: | 1087-1845 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1087184510001325 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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dinamarco2010.pdf Acesso restrito! | 1,24 MB | Adobe PDF | Ver/Abrir |