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https://hdl.handle.net/1822/67360
Título: | TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-γ |
Autor(es): | Resende, Mariana Cardoso, Marcos S. Fróis-Martins, Ricardo Borges, Margarida Jordan, Michael B. Castro, António G. Appelberg, Rui |
Palavras-chave: | Animals CD4-Positive T-Lymphocytes Granuloma Interferon-gamma Macrophage Activation Mice Mice, Inbred C57BL Mycobacterium avium Signal Transduction Tumor Necrosis Factor-alpha |
Data: | Nov-2019 |
Editora: | American Association of Immunologists |
Revista: | The Journal of Immunology |
Citação: | Resende, M., Cardoso, M. S., Fróis-Martins, R., et. al. (2019). TNF-Mediated Compensatory Immunity to Mycobacterium avium in the Absence of Macrophage Activation by IFN-γ. The Journal of Immunology, 203(9), 2451-2458 |
Resumo(s): | Granuloma formation is a hallmark of several infectious diseases, including those caused by Mycobacterium sp These structures are composed of accumulations of inflammatory cells, and it has been shown that cytokines such as IFN-γ and TNF-α are required for granuloma assembly during M. avium infections in mice. Macrophages (MΦs) insensitive to IFN-γ (MIIG) mice have MΦs, monocytes, and dendritic cells that are unresponsive to IFN-γ. We observed that although IFN-γ-/- mice present an exacerbated infection, the same is not true for MIIG animals, where the same levels of protection as the wild-type animals were observed in the liver and partial protection in the spleen. Unlike IFN-γ-/- mice, MIIG mice still develop well-defined granulomas, suggesting that IFN-γ-mediated MΦ activation is not required for granuloma assembly. This work also shows that MIIG animals exhibit increased cell recruitment with higher CD4+ T cells numbers as well as increased IFN-γ and TNF-α expression, suggesting that TNF-α may have a role in protection and may compensate the lack of MΦ response to IFN-γ in the MIIG model. TNF-α-deficient MIIG mice (MIIG.TNF-α-/-) exhibited increased bacterial burdens when compared with MIIG mice. These results suggest that in the absence of IFN-γ signaling in MΦs, TNF-α has a protective role against M. avium. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67360 |
DOI: | 10.4049/jimmunol.1801594 |
ISSN: | 0022-1767 |
e-ISSN: | 1550-6606 |
Versão da editora: | https://www.jimmunol.org/content/203/9/2451.abstract |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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resende2019.pdf Acesso restrito! | 2,07 MB | Adobe PDF | Ver/Abrir |