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TitleAging Hallmarks: the benefits of physical exercise
Author(s)Rebelo-Marques, Alexandre
De Sousa Lages, Adriana
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
physical exercise
life span
Issue date2018
PublisherFrontiers Media
JournalFrontiers in Endocrinology
CitationRebelo-Marques A, De Sousa Lages A, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F and Espregueira-Mendes J (2018) Aging Hallmarks: The Benefits of Physical Exercise. Front. Endocrinol. 9:258. doi: 10.3389/fendo.2018.00258
Abstract(s)World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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