Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65828
Título: | Aging Hallmarks: the benefits of physical exercise |
Autor(es): | Rebelo-Marques, Alexandre De Sousa Lages, Adriana Andrade, Renato Ribeiro, Carlos Fontes Mota-Pinto, Anabela Carrilho, Francisco Espregueira-Mendes, João |
Palavras-chave: | aging physical exercise hallmarks cellular molecular life span |
Data: | 2018 |
Editora: | Frontiers Media |
Revista: | Frontiers in Endocrinology |
Citação: | Rebelo-Marques A, De Sousa Lages A, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F and Espregueira-Mendes J (2018) Aging Hallmarks: The Benefits of Physical Exercise. Front. Endocrinol. 9:258. doi: 10.3389/fendo.2018.00258 |
Resumo(s): | World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65828 |
DOI: | 10.3389/fendo.2018.00258 |
ISSN: | 1664-2392 |
Versão da editora: | https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fendo-09-00258.pdf | 563,94 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons