Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/63386
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gabriela-Freitas, Maria | por |
dc.contributor.author | Pinheiro, Joana | por |
dc.contributor.author | Raquel-Cunha, Ana | por |
dc.contributor.author | Cardoso-Carneiro, Diana | por |
dc.contributor.author | Martinho, Olga | por |
dc.date.accessioned | 2020-01-24T12:50:49Z | - |
dc.date.available | 2020-01-24T12:50:49Z | - |
dc.date.issued | 2019-11-22 | - |
dc.identifier.citation | Gabriela-Freitas, M.; Pinheiro, J.; Raquel-Cunha, A.; Cardoso-Carneiro, D.; Martinho, O. RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer. Biomolecules 2019, 9, 769. | por |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://hdl.handle.net/1822/63386 | - |
dc.description.abstract | Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or loss of expression, is correlated not only with the presence of metastasis, contributing to RKIP’s classification as a metastasis suppressor, but also with tumour aggressiveness and poor prognosis. Recent findings suggest a strong involvement of RKIP in the modulation of tumour microenvironment components, particularly by controlling the infiltration of specific immune cells and secretion of pro-metastatic factors. Additionally, RKIP interaction with multiple signalling molecules seems to potentiate its function as a regulator of inflammatory processes, mainly through stimulation of anti- or pro-inflammatory cytokines. Furthermore, RKIP is involved in the modulation of immunotherapeutic drugs response, through diverse mechanisms that sensitize cells to apoptosis. In the present review, we will provide updated information about the role of RKIP as an inflammatory and immune modulator and its potential implications in cancer will be addressed. | por |
dc.description.sponsorship | This study was partially developed under the scope of the projects: PTDC/MED-ONC/31423/2017 (Ref: POCI-01-0145-FEDER-031423) by FEDER funds through the Operational Programme Competitiveness Factors - COMPETE and National Funds through FCT - Foundation for Science and Technology; NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). Diana Cardoso-Carneiro and Ana Raquel-Cunha are recipients of PhD fellowships (SFRH/BD/141200/2018 and SFRH/BD/148199/2019, respectively) from FCT, and Olga Martinho is an auxiliary researcher from the above cited project: NORTE-01-0145-FEDER-000023. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | PTDC/MED-ONC/31423/2017 | por |
dc.relation | SFRH/BD/141200/2018 | por |
dc.relation | SFRH/BD/148199/2019 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | RKIP | por |
dc.subject | tumour microenvironment | por |
dc.subject | inflammation | por |
dc.subject | immunomodulation | por |
dc.title | RKIP as an inflammatory and immune system modulator: implications in cancer | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2218-273X/9/12/769 | por |
oaire.citationIssue | 769 | por |
oaire.citationVolume | 9 | por |
dc.date.updated | 2019-12-20T14:09:51Z | - |
dc.identifier.doi | 10.3390/biom9120769 | por |
dc.identifier.pmid | 31766768 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomolecules | por |
oaire.version | VoR | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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biomolecules-09-00769-v2.pdf | 1,97 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons