Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62501

TitleComparison of a new-generation fecal immunochemical test (FIT) with guaiac fecal occult blood test (gFOBT) in detecting colorectal neoplasia among colonoscopy-referral patients
Author(s)Guimarães, Denise Peixoto
Fregnani, Jose Humberto
Reis, R. M.
Taveira, Leonardo Nogueira
Scapulatempo-Neto, Cristovam
Matsushita, Marcus
Silva, Sandra Regina Morini
Oliveira, Ceyton Zanardo
Longatto, Adhemar
Eklund, Carita
Paloheimo, Lea
Mauad, Edmundo
Suovaniemi, Osmo
Syrjänen, Kari
KeywordsAdenocarcinoma
Adenoma
Aged
Biopsy
Colonoscopy
Colorectal Neoplasms
Diagnosis, Differential
Early Detection of Cancer
Feces
Female
Guaiac
Humans
Immunochemistry
Male
Mass Screening
Middle Aged
Neoplasms
Occult Blood
Colorectal cancer
Screening
Fecal occult blood (FOB) Colorectal cancer screening fecal occult blood (FOB) guaiac-based FOB test (gFOBT) fecal immunochemical test (FIT) p Colorectal cancer screening fecal occult blood (FOB) guaiac-based FOB test (gFOBT) fecal immunochemical test (FIT) pee
Guaiac-based FOB test (gFOBT)
Fecal immunochemical test (FIT)
Performance colonoscopy
fecal occult blood (FOB)
performance
Issue dateJan-2019
PublisherInternational Institute of Anticancer Research (IIAR)
JournalAnticancer Research
CitationGuimaraes, D. P., Fregnani, J. H., Reis, R. M., et. al. (2019). Comparison of a New-generation Fecal Immunochemical Test (FIT) With Guaiac Fecal Occult Blood Test (gFOBT) in Detecting Colorectal Neoplasia Among Colonoscopy-referral Patients. Anticancer research, 39(1), 261-269.
Abstract(s)The aim of the present study was to compare fecal immunochemical tests (FITs) for colorectal cancer (CRC) screening with the traditional guaiac-based FOB tests (gFOBT). Background/Aim: The aim of the present study was to compare fecal immunochemical tests (FITs) for colorectal cancer (CRC) screening with the traditional guaiac-based FOB tests (gFOBT). Materials and Methods: A cohort of 368 colonoscopy-referral patients were evaluated by i) the new-generation FIT: ColonView quick test (CV; Biohit Oyj, Finland) and ii) a conventional gFOBT HemoccultSENSA (HS; Beckman Coulter, USA). Three fecal samples were requested for both assays, and all subjects underwent diagnostic colonoscopy with biopsy confirmation. Sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV) and area under curve (AUC) were calculated for both tests using three endpoints: adenoma (A), advanced adenoma (AA) and adenocarcinoma (AC). Results: Colonoscopy and biopsies disclosed normal mucosa in 90/378 (24.5%) subjects, early A in 108/368 (29.3%) cases, AA in 48/368 (13.0%) and AC in 37/368 (10.1%), and non-neoplastic conditions in the remaining 85 (30.3%). For the AC endpoint, the CV (Hb/Hp) test had 94.6% SE and 65.1% SP (AUC=0.799), while the HS test had SE of 75.7% and SP of 84.3% (AUC=0.800). For the A endpoint, the difference between CV and HS was even more pronounced; SE of 44.2% and 19.2%, respectively (p<0.0001). Hb and Hb/Hp complex of the CV test showed equal performance for all endpoints. Conclusion: Sensitivity (94.6%) of the ColonView quick test for the most reproducible endpoint (invasive CRC) far exceeded the pooled sensitivity (79%) estimated in a recent meta-analysis for 8 common FIT brands. As shown in a previous study, ColonView quick test is superior in SE to HemoccultSENSA test, making CV a perfect FIT for organized CRC screening
TypeArticle
URIhttp://hdl.handle.net/1822/62501
DOI10.21873/anticanres.13106
ISSN0250-7005
e-ISSN1791-7530
Publisher versionhttp://ar.iiarjournals.org/content/39/1/261.short
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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