Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62413

TitleSerum lactate levels are associated with glioma malignancy grade
Author(s)Branco, Mariana
Linhares, Paulo
Carvalho, Bruno
Santos, Patrícia
Costa, Bruno Marques
Vaz, Rui
KeywordsGlioma
Lactate
Biomarker
Diagnosis
Neuro-oncology
Neurosurgery
Issue dateNov-2019
PublisherElsevier
JournalClinical Neurology and Neurosurgery
Abstract(s)Objective Recent studies have suggested that high grade gliomas are associated with elevated serum lactate concentrations. The aim of the present study is to assess these findings in a sample of patients. Patients and methods We reviewed the anesthetic charts of patients with low-grade and high-grade glioma who underwent resection surgery and collected serum lactate concentration before tumor resection, as well as other demographic and tumor-related data (age, gender, WHO grade, and size of the tumor). A statistical comparison between patients with normal (<2 mmol/L) and elevated (≥ 2 mmol/L) serum lactate was performed. Results We included a total of 152 patients (mean age 49.07 years). 62.5% of patients (n = 95) had a high-grade glioma and 37.5% (n = 67) a low-grade glioma. The multivariate regression showed that high grade gliomas had significantly higher lactate concentration (p < 0.01). The OR for elevated pre-resection serum lactate increased from 4.94 to 14.33 after adjusting for age and pre-surgical corticosteroid use, and the AUC for the final regression model was 0.98. Conclusion This study reinforces the role of serum lactate as a potential biomarker of brain tumors malignancy, and its results encourage further research on this subject, in order to improve the understanding of this phenomenon and to assess its potential as prognostic and therapeutic monitoring tool.
TypeArticle
URIhttp://hdl.handle.net/1822/62413
DOI10.1016/j.clineuro.2019.105546
ISSN0303-8467
e-ISSN1872-6968
Peer-Reviewedyes
AccessEmbargoed access (1 Year)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
serum lactate are associated with glioma malignancy grade.pdf
  Until 2020-12-01
176,55 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID