Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62160

TitleTh17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines
Author(s)Iannitti, Rossana G.
Carvalho, Agostinho
Cunha, Cristina
De Luca, Antonella
Giovannini, Gloria
Casagrande, Andrea
Zelante, Teresa
Vacca, Carmine
Fallarino, Francesca
Puccetti, Paolo
Massi-Benedetti, Cristina
Defilippi, Gloria
Russo, Maria
Porcaro, Luigi
Colombo, Carla
Ratclif, Luigi
De Benedictis, Fernando M.
Romani, Luigina
KeywordsAnimals
Cystic Fibrosis
Forkhead Transcription Factors
Immunohistochemistry
In Situ Nick-End Labeling
Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Mice
Mice, Inbred C57BL
T-Lymphocytes, Regulatory
Th17 Cells
Up-Regulation
Aspergillosis
indoleamine 2,3-dioxygenase
Th17/Treg balance
Issue date15-Mar-2013
PublisherAmerican Thoracic Society
JournalAmerican Journal of Respiratory and Critical Care Medicine
CitationIannitti, R. G., Carvalho, A., Cunha, C., et. al. (2013). Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2, 3-dioxygenase deficiency but corrected by kynurenines. American journal of respiratory and critical care medicine, 187(6), 609-620.
Abstract(s)Mutations in the cystic fibrosis (CF) transmembrane conductance regulator affect the innate epithelial immune function of the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pathogenic fungi. The appreciation of whether such fungi are primarily responsible for or a consequence of ineffective airway inflammation is important for future therapeutics development.
TypeArticle
URIhttp://hdl.handle.net/1822/62160
DOI10.1164/rccm.201207-1346OC
ISSN1073-449X
e-ISSN1535-4970
Publisher versionhttps://www.atsjournals.org/doi/full/10.1164/rccm.201207-1346OC
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
fulltext.pdf3,29 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID