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TitleTh17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines
Author(s)Iannitti, Rossana G.
Carvalho, Agostinho
Cunha, Cristina
De Luca, Antonella
Giovannini, Gloria
Casagrande, Andrea
Zelante, Teresa
Vacca, Carmine
Fallarino, Francesca
Puccetti, Paolo
Massi-Benedetti, Cristina
Defilippi, Gloria
Russo, Maria
Porcaro, Luigi
Colombo, Carla
Ratclif, Luigi
De Benedictis, Fernando M.
Romani, Luigina
Cystic Fibrosis
Forkhead Transcription Factors
In Situ Nick-End Labeling
Indoleamine-Pyrrole 2,3,-Dioxygenase
Mice, Inbred C57BL
T-Lymphocytes, Regulatory
Th17 Cells
indoleamine 2,3-dioxygenase
Th17/Treg balance
Issue date15-Mar-2013
PublisherAmerican Thoracic Society
JournalAmerican Journal of Respiratory and Critical Care Medicine
CitationIannitti, R. G., Carvalho, A., Cunha, C., et. al. (2013). Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2, 3-dioxygenase deficiency but corrected by kynurenines. American journal of respiratory and critical care medicine, 187(6), 609-620.
Abstract(s)Mutations in the cystic fibrosis (CF) transmembrane conductance regulator affect the innate epithelial immune function of the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pathogenic fungi. The appreciation of whether such fungi are primarily responsible for or a consequence of ineffective airway inflammation is important for future therapeutics development.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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