Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62141
Título: | EGFR and microvessel density in canine malignant mammary tumours |
Autor(es): | Carvalho, Maria Isabel Guimarães, Maria João Pires, Isabel Prada, Justina Carvalho, Ricardo Emanuel Silva Lopes, Carlos Queiroga, Felisbina L. |
Palavras-chave: | Animals Dog Diseases Dogs ErbB Receptors Female Gene Expression Regulation, Neoplastic Mammary Neoplasms, Animal Microvessels Neoplasm Metastasis Neovascularization, Pathologic Platelet Endothelial Cell Adhesion Molecule-1 EGFR Angiogenesis MVD CD31 Canine mammary tumours |
Data: | Dez-2013 |
Editora: | Elsevier |
Revista: | Research in Veterinary Science |
Citação: | Carvalho, M. I., Guimarães, M. J., Pires, I., Prada, J., Silva-Carvalho, R., Lopes, C., & Queiroga, F. L. (2013). EGFR and microvessel density in canine malignant mammary tumours. Research in veterinary science, 95(3), 1094-1099. |
Resumo(s): | The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor which has been shown to have an important role in human breast cancer. Its role appears to be associated with increased angiogenesis and metastasis. In order to clarify its role in canine mammary tumours (CMT), 61 malignant neoplasms were studied by using immunohistochemistry, comparing expression of EGFR, microvessel density (MVD) by CD31 immunolabelling and characteristics of tumour aggressiveness. High EGFR immunoexpression was statistically significantly associated with tumour size, tumour necrosis, mitotic grade, histological grade of malignancy and clinical stage. High CD31 immunoreactivity was statistically significantly associated with tubule formation, histological grade of malignancy and clinical stage. A positive correlation between EGFR and CD31 immunoexpression (r = 0.843; P < 0.001) was also observed. Results suggest that an over-expression of EGFR may contribute to increased angiogenesis and aggression in malignant CMT, presenting the possibility of using EGFR inhibitors in the context of metastatic disease treatment. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62141 |
DOI: | 10.1016/j.rvsc.2013.09.003 |
ISSN: | 0034-5288 |
e-ISSN: | 1532-2661 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0034528813003032 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S0034528813003032-main.pdf Acesso restrito! | 1,77 MB | Adobe PDF | Ver/Abrir |