Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62085
Título: | Statin-related myotoxicity |
Autor(es): | Fernandes, Vera Santos, Maria Joana Pérez, Antonio |
Palavras-chave: | Clinical Trials as Topic Comorbidity Creatine Kinase Cytochrome P-450 CYP3A Dietary Supplements Disease Management Disease Susceptibility Drug Interactions Drug Substitution Exercise Ezetimibe Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Incidence Male Meta-Analysis as Topic Muscular Diseases Rhabdomyolysis Risk Factors Statins HMG-CoA reductase inhibitors Ditag-related side effect Statin intolerance Myotoxicity Myopathy Drug-related side effects |
Data: | Mai-2016 |
Editora: | Elsevier España |
Revista: | Endocrinologia y Nutricion |
Resumo(s): | Statin therapy has a very important role in decreasing cardiovascular risk, and treatment non-compliance may therefore be a concern in high cardiovascular risk patients. Myotoxicity is a frequent side effect of statin therapy and one of the main causes of statin discontinuation, which limits effective treatment of patients at risk of or with cardiovascular disease. Because of the high proportion of patients on statin treatment and the frequency of statin-related myotoxicity, this is a subject of concern in clinical practice. However, statin-related myotoxicity is probably underestimated because there is not a gold standard definition, and its diagnosis is challenging. Moreover, information about pathophysiology and optimal therapeutic options is scarce. Therefore, this paper reviews the knowledge about the definition, pathophysiology and predisposing conditions, diagnosis and management of statin-related myotoxicity, and provides a practical scheme for its management in clinical practice. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62085 |
DOI: | 10.1016/j.endonu.2016.01.001 |
ISSN: | 1575-0922 |
e-ISSN: | 1579-2021 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S2173509316300289 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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statin related miotoxicity.pdf Acesso restrito! | 1,09 MB | Adobe PDF | Ver/Abrir |