Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61998

Full metadata record
DC FieldValueLanguage
dc.contributor.authorRamos, Patríciapor
dc.contributor.authorSantos, Agostinhopor
dc.contributor.authorPinto, Nair Rosaspor
dc.contributor.authorMendes, Ricardopor
dc.contributor.authorMagalhães, Teresapor
dc.contributor.authorAlmeida, Agostinhopor
dc.date.accessioned2019-11-08T16:34:39Z-
dc.date.issued2014-11-
dc.identifier.citationRamos, P., Santos, A., Pinto, N. R., Mendes, R., Magalhães, T., & Almeida, A. (2014). Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain. Biological trace element research, 161(2), 190-201.por
dc.identifier.issn0163-4984-
dc.identifier.urihttp://hdl.handle.net/1822/61998-
dc.description.abstractUsing inductively coupled plasma-mass spectrometry after samples microwave-assisted acid digestion, zinc (Zn), copper (Cu), and manganese (Mn) levels were measured in 14 different areas of the human brain of adult individuals (n = 42; 71 ± 12, range 50-101 years old) without a known history of neurodegenerative, neurological, or psychiatric disorder. The main goals of the work were to establish the "normal" (reference) values for those elements in the human brain and to evaluate the age-related changes, a prior and indispensable step in order to enlighten the role of trace element (TE) in human brain physiology and their involvement in aging and neurodegenerative processes. Considering the mean values for the 14 regions, Zn (mean ± sd; range 53 ± 5; 43-61 μg/g) was found at higher levels, followed by Cu (22 ± 5; 10-37 μg/g) and Mn (1.3 ± 0.3; 0.5-2.7 μg/g). The TE distribution across the brain tissue showed to be quite heterogeneous: the highest levels of Zn were found in the hippocampus (70 ± 10; 49-95 μg/g) and superior temporal gyrus (68 ± 10; 44-88 μg/g) and the lowest in the pons (33 ± 8; 19-51 μg/g); the highest levels of Cu and Mn were found in the putamen (36 ± 13; 21-76 μg/g and 2.5 ± 0.8; 0.7-4.5 μg/g, respectively) and the lowest in the medulla (11 ± 6; 2-30 μg/g and 0.8 ± 0.3; 0.2-1.8 μg/g, respectively). A tendency for an age-related increase in Zn and Mn levels was observed in most brain regions while Cu levels showed to be negatively correlated with age.por
dc.description.sponsorshipUniversidade do Porto and Santander Totta for financial support through the project “TRAIN: Trace elements in human brain: age-related changes and anatomic region specific differences” (PP_IJUP 2011 342)por
dc.language.isoengpor
dc.publisherSpringerpor
dc.rightsrestrictedAccesspor
dc.subjectAgedpor
dc.subjectAged, 80 and overpor
dc.subjectAgingpor
dc.subjectBrain Chemistrypor
dc.subjectCopperpor
dc.subjectFemalepor
dc.subjectHumanspor
dc.subjectMalepor
dc.subjectManganesepor
dc.subjectMiddle Agedpor
dc.subjectPutamenpor
dc.subjectZincpor
dc.subjectHuman brainpor
dc.subjectPostmortem analysispor
dc.subjectInductively coupled plasma-mass spectrometrypor
dc.titleAnatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brainpor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s12011-014-0093-6#citeaspor
oaire.citationStartPage190por
oaire.citationEndPage201por
oaire.citationIssue2por
oaire.citationVolume161por
dc.identifier.essn1559-0720-
dc.identifier.doi10.1007/s12011-014-0093-6por
dc.date.embargo10000-01-01-
dc.identifier.pmid25119708por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalBiological Trace Element Researchpor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Ramos-2014-Anatomical-region-differences-and-a.pdf
  Restricted access
1,28 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID